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[摘要]
目的 观察丹红注射液联合奥扎格雷钠对老年性脑梗死合并高血压病的临床疗效。方法 将160例脑梗死合并高血压病老年患者随机分为对照组和观察组各80例,对照组给予奥扎格雷钠160 mg,每天1次;观察组在对照组基础上给予丹红注射液20 mL,每天1次。2周为1个疗程。观察两组临床疗效,比较治疗前后临床神经功能缺损程度评分(NDS)、Barthel指数评定量表(BI)、血压以及不良反应。结果 观察组总有效率为93.75%,对照组总有效率为75.00%,观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,观察组NDS评分为(24.01±7.61)分,BI评分为(38.14±6.42)分,对照组NDS评分为(24.08±7.93)分,BI评分为(38.45±8.02)分,两组治疗前NDS及BI比较,差异无统计学意义;治疗后,观察组NDS评分为(13.81±3.91)分,BI评分为(59.11±7.12)分,对照组NDS评分为(15.50±4.32)分,BI评分为(50.92±6.48)分,两组治疗后NDS及BI均明显优于治疗前,差异有统计学意义(P<0.05)。且治疗后观察组NDS及BI均明显优于对照组,差异有统计学意义(P<0.05)。治疗前,观察组患者平均收缩压(SBP)为(165.0±6.8)mmHg,平均舒张压(DBP)为(101.0±5.9)mmHg,对照组患者SBP(167.0±7.6)mmHg,DBP(102.0±6.6)mmHg;治疗后,观察组患者SBP(138.0±7.6)mmHg,DBP(78.0±6.7)mmHg,对照组患者SBP(135.0±8.1)mmHg,DBP(80.0±7.2)mmHg,各组治疗前后SBP和DBP比较,差异均有统计学意义(P<0.05),但两组之间差异无统计学意义。两组患者不良反应比较差异无统计学意义。结论 奥扎格雷钠联合丹红注射液对老年脑梗死合并高血压病临床疗效明显优于单用奥扎格雷钠,且无严重不良反应,值得临床推广应用。
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[Abstract]
Objective To observe the curative effect of Sodium Ozagrel combined with Danhong Injection in the treatment of senile cerebral infarction with hypertension. Methods We selected 160 cases of senile cerebral infarction with hypertension and the patients were randomly divided into control group and observation group, 80 cases in each group. The patients in control group were given Sodium Ozagrel (160 mg), once daily, while the patients in observation group were treated with sodium ozagrel (160 mg) combined with Danhong Injection (20 mL), once daily, two weeks for a course of treatment. The cinical effects of the two groups were observed after a course of treatment. NDS, BI, blood pressure, and adverse reactions were compared before and after treatment. Results The total effective rates of observation group and control group were 93.75% and 75%. The total effective rate in the observation group was significantly higher than that in the control group (P<0.05). Before treatment, the NDS score of observation group was (24.01±7.61), the BI score was (38.14±6.42), the NDS score of the control group was (24.08±7.93), the BI score was (38.45±8.02). The difference was not statistically significant. After treatment, the NDS score of the observation group was (13.81±3.91), the BI score was (59.11±7.12), the NDS score of the control group was (15.50±4.32), the BI score was (50.92±6.48). After treatment, the BI and NDS in the observation group were significantly better than those in the control group (P<0.05). After treatment, BI and NDS of two groups were significantly better than those before treatment (P<0.05). Before treatment, the average systolic blood pressure (SBP) of observation group was (165.0±6.8) mmHg and mean diastolic blood pressure (DBP) was (101.0±5.9) mmHg, SBP of control group was (167.0±7.6) mmHg, DBP was (102.0±6.6) mmHg; after treatment, the observation groups of patients with SBP (138.0±7.6) mmHg, DBP (78.0±6.7) mmHg, control group patients with SBP (135.0±8.1) mmHg, DBP (80.0±7.2) mmHg, differences before and after the treatment in the same group were statistically significant (P<0.05), but the difference between the two groups has no statistical significance. There was no significant difference in adverse reactions between the two groups. Conclusion Sodium Ozagrel combined with Danhong Injection has better effect for treating senile cerebral infarction with hypertension and without any toxic and serious side effect. It is worthy of promotion in clinic.
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