目的 探讨卡前列素氨丁三醇、米索前列醇和缩宫素联合应用治疗产后出血的疗效。方法 选择2013年2月-2015年9月在渭南市妇幼保健院进行诊治的产后出血患者100例,随机分为两组,其中观察组55例,给予卡前列素氨丁三醇、米索前列醇和缩宫素联合治疗;对照组45例,给予缩宫素治疗,观察两组的临床疗效、术中出血量、术后2 h出血量、术后24 h出血量、产后出血持续时间和住院时间,记录两组不良反应的发生情况。结果 与对照组相比,观察组的术中出血量、术后2 h出血量和术后24 h出血量均明显减少(P<0.05);观察组的治疗总有效率为92.73%(51/55),明显高于对照组80.00%(36/45)(P<0.05);观察组的产后出血持续时间和住院时间均明显短于对照组,差异有统计学意义(P<0.05);两组间不良反应发生率相比,差异无统计学意义。结论 卡前列素氨丁三醇、米索前列醇和缩宫素联合应用治疗产后出血疗效显著,能够有效减少术后出血量,缩短止血时间和住院时间,安全有效,值得临床应用推广。

Objective To explore the clinical effective of carboprost tromethamine and misoprostol combined with oxytocin in treatment of postpartum hemorrhage. Methods Totally 100 cases of patients with postpartum hemorrhage were treated in Weinan Matemty and Child Health Care Hospital from January 2013 to September 2015, and they were randomly divided into observation group (55 cases) and control group (45 cases). The patients in observation group were treated with carboprost tromethamine and misoprostol combined with oxytocin, the control group was treated with oxytocin. The clinical effect of the two groups, the amount of intraoperative hemorrhage volume, postoperative 2 h bleeding, postoperative 24 h bleeding volume, duration time of postpartum hemorrhage and hospitalization time, and occurrence of adverse reactions in the two groups were observed. Results Compared with the control group, the amounts of blood loss, 2 h postoperative bleeding volume, and 24 h postoperative bleeding volume were significantly decreased (P<0.05); The total effective rate of observation group was 92.73% (51/55) which was significantly higher than that in control group 80.00% (36/45) (P<0.05); The duration time of postpartum hemorrhage and hospitalization time in the observation group were significantly shorter than tht in control group (P<0.05); The adverse reaction rate between the two groups was not statistically significant. Conclusion The curative effect of carboprost tromethamine, misoprostol combined with oxytocin in treatment of postpartum hemorrhage is remarkable, can effectively reduce the amount of bleeding, shorten the time of bleeding and hospitalization time, safe and effective, which is worthy of clinical application.