[关键词]
[摘要]
目的 研究应用槐杞黄颗粒治疗呼吸道合胞病毒(RSV)毛细支气管炎患儿的临床疗效及对患儿免疫功能的调节作用。方法 将大连大学附属中山医院儿科收治的73例RSV毛细支气管炎患儿采用随机数字表法分为研究组36例和对照组37例,两组患儿均给予化痰、止咳、平喘、抗感染治疗,研究组患儿给予槐杞黄颗粒治疗,比较两组患儿治疗1个月后的临床疗效、免疫水平指标的变化情况。结果 研究组的咳嗽时间(5.3±1.8)d、气促时间(2.7±1.4)d、肺部哮鸣音(4.9±1.6)d、肺部啰音(5.2±1.7)d、住院时间(6.8±1.7)d均显著低于对照组患儿,且差异均具有统计学意义(P<0.05)。治疗前研究组和对照组的血清免疫球蛋白E(IgE)、免疫球蛋白-M(IgM)、免疫球蛋白-A(IgA)、免疫球蛋白-G(IgG)、γ-干扰素(INF-γ)、白细胞介素-4(IL-4)检出值差异不具有统计学意义,治疗后1个月复查,两组患儿的IgE、IgA、INF-γ、IL-4检出值均较治疗前好转且差异均具有统计学意义(P<0.05);研究组的IgE、IL-4检出值较对照组显著降低,IgA、INF-γ检出值较对照组显著升高,且差异均具有统计学意义(P<0.05)。研究组的治疗显效率为86.11%,显著高于对照组患儿的62.16%,且差异均具有统计学意义(P<0.05);研究组治疗后的有效率97.22%高于对照组患儿的91.89%,但差异不具有统计学意义。结论 槐杞黄颗粒对RSV毛细支气管炎患儿具有调节体液免疫的功能,同时可以促进患儿临床症状的缓解,有利于提高治疗效果。
[Key word]
[Abstract]
Objective Research on the clinical curative effect of Huaiqihuang Granule in the treatment of respiratory tract virus (RSV) bronchiolitis and regulative effect on immune function of children. Methods Totally 73 cases of RSV bronchiolitis from department of pediatrics of Zhongshan Hospital affiliated to Dalian University were randomly divided into treatment group (36 cases) and control group (37 cases). Two groups of children were given the expectorant, antitussive, anti-asthmatic, and anti-infection treatment, the patients in treatment group were given Huaiqihuang Granules. The changes of clinical therapeutic effect and immune index in two groups after treatment for 1 month were compared. Results The time of cough was (5.3±1.8) d, shortness of breath time was (2.7±1.4) d, and lung roar cries sound time was (4.9±1.6) d, pulmonary rales time was (5.2±1.7) d, and length of hospital stay was (6.8±1.7) d in research group, which were significantly lower than those in the control group and the difference was statistically significant (P<0.05). Before treatment, the levels of IgE, IgM, IgA, IgG, INF-γ, and IL-4 in treatment group and control group had no statistical significance. After treatment for 1 month, the detection values of IgE, IgA, INF-γ, and IL-4 in two groups were all better than those before treatment and the difference was statistically significant (P<0.05). The IgE and IL-4 levels in treatment group were significantly lower than the control group, the detection values of IgA, INF-γ was significantly higher than the control group (P<0.05). The markedly effective rate of research group was 86.11%, significantly higher than that of control group with 62.16% (P<0.05); after treatment, the effective rate of study group was 97.22%, higher than that of the control group with 91.89%, but the difference is not statistically significant. Conclusion Huaiqihuang Granule could regulate the function of humoral immunity in children with RSV bronchiolitis, at the same time, it could promote the relief of clinical symptoms of patients, could improve the therapeutic effect.
[中图分类号]
[基金项目]