齐墩果酸和熊果酸同属五环三萜酸类化合物,它们又是同分异构体.药理作用几乎相同,都具有抗氧化、抗炎、免疫调节、抗肿瘤、抗微生物、保肝、抗糖尿病、调脂、减肥、抗动脉粥样硬化作用.综述齐墩果酸和熊果酸保护神经细胞、镇痛、抗焦虑、抗神经分裂症、抗抑郁、改善学习记忆等神经精神药理作用,为齐墩果酸和熊果酸防治老年痴呆、帕金森病和抑郁症的研发提供依据.

Oleanolic acid and ursolic acid belong to pentacyclic triterpenoid carboxylic acid, and are isomers yet. Their pharmacologic effects are full alike. Oleanolic acid and ursolic acid have the effects of anti-oxidation, anti-inflammation, immune regulation, antitumor, antimicrobe, hepatoprotection, antidiabetes, lipidemic regulation, anti-obesity, and anti-atherosclerosis. In this paper, the literature data on neuropsychopharmacologic effects of oleanolic acid and ursolic acid in neuroprotection, antinociception, anti-anxiety, anti-schizophrenia, antidepression, improvement of study and memory, etc. are reviewed, so as to provide the basis for the research and development of the prevention and treatment for Alzheimer's disease, Parkinson disease, and depression.