目的 观察北京燕化医院2011-2014年防治慢性乙型肝炎药物的使用情况,为抗肝炎药物的临床合理应用提供依据。方法 统计该院2011-2014年住院与门诊患者防治慢性乙肝药物的使用情况、药物种类及用药频度(DDDs)、日均费用(DDC)等,并对安全性及耐药性进行总结与分析。结果 该院常用的防治慢性乙型肝炎药物主要为干扰素与核苷(酸)类,核苷类药物所占比例较大,在2011-2014年中药品构成排序发生变化,由于拉夫米定的耐药性导致其使用率逐渐下降,恩替卡韦使用率逐渐上升,阿福韦德使用率上升后降低。结论 抗病毒治疗成为防治慢性乙型肝炎的重要方法,应该结合药物特点及患者实际情况,合理规范使用干扰素及核苷(酸)类药物,优化治疗方案,加强临床耐药管理,降低药物耐药率。

Objective To observe the clinical use of anti-hepatitis therapy on chronic hepatitis B in Beijing Yanhua Hospital in 2011-2014, in order to provide basis for the rational administration of anti-hepatitis drugs. Methods The application of anti-hepatitis therapy on chronic hepatitis B in Beijing Yanhua Hospital in 2011-2014 were recorded, including the drug type and frequency of use and costs, irrational drug use prevention and treatment of chronic hepatitis cases are classified statistics. Results The interferon and nucleoside (acid) category were used primarily for prevention and treatment of chronic hepatitis B of our hospital in 2011-2014, nucleoside drugs had a larger proportion. Medicines constitute ordering changed in 2011-2014, due to lamivudine resistance led to decreased utilization; Entecavir utilization increased gradually, Fu Wade usage increased after lowering. Conclusion It shows that antiviral therapy has become an important method for the prevention and treatment of chronic hepatitis B, and the drug should be combined with patient characteristics and actual situation. The reasonable and standard usage of interferon and nucleoside (acid), optimization of treatment options, clinical resistance management and reduction of drug resistance should be performed.