目的 观察血必净注射液对经皮肾镜碎石术(PCN)后全身炎症反应综合征(SIRS)的治疗效果。方法 PCN术后并发SIRS患者58例, 按随机数字表法分为常规治疗组(28例)和血必净组(30例)。常规治疗组患者给予左氧氟沙星注射液300 mg静脉滴注, 2次/d;血必净组在对照组的基础上加用血必净注射液50 mL+0.9氯化钠注射液100 mL静脉滴注, 2次/d。两组患者均治疗14 d。常规监测患者的心率(HR)、呼吸频率(RR)、体温(T)、白细胞计数(WBC)以及SIRS及其症状改善时间, 并观察两组患者第1天和第14天血清中TNF-α、IL-6浓度变化。结果 常规治疗组和血必净组的临床有效率分别为46.43%和76.67%, 两组比较差异具有显著性(P<0.05)。治疗后HR、RR、T、WBC均有改善, 与治疗前相比差异显著(P<0.05), 但两组间各项指标差异均无显著性。血必净组HR、RR、T、WBC恢复时间明显优于常规治疗组(P<0.05)。治疗后两组患者TNF-α、IL-6均得到明显改善(P<0.05), 且两组间比较有显著性差异, 血必净组优于常规治疗组(P<0.05)。结论 血必净注射液能有效抑制PCN术后过激炎症反应, 明显改善SIRS症状。

Objective To observe the effects of Xuebijing Injection on the treatment results of systemic inflammatory response syndrome (SIRS) induced by undergoing percutaneous nephrolithotomy (PCN). Methods The 58 cases with SIRS induced by PCN in the Department of Urology Surgery, Haikou People's Hospital from September 2012 to October 2013 were randomly divided into conventional therapy group (28 cases) and Xuebijing Injection Group (30 patients) by digital table method. The patients in the control group were treated with iv infusion of Levofloxacin Injection 300 mg, 2 times/d; The patients in the Xuebijing Injection group on the basis of the control treatment group were added Xuebijing Injection 50 mL + 0.9 sodium chloride injection by iv infusion of 100 mL, 2 times/d. The patients in the two groups were treated in 14 d, the changes of serum concentrations of TNF-α, IL-6 between the two groups were obserbed on day 1, 3, 5, and 7, and heart rate (HR), respiratory rate (RR), temperature (t), white blood cell count (WBC), and SIRS symptom improvement time were routinely monitored. Results The clinical efficiencies of the conventional therapy and Xuebijing Injection are 46.43% and 76.67%, respectively. After statistical analysis, the statistical difference (P < 0.05) between the two groups was significant. Conclusion Xuebijing Injection could effectively inhibit the PCN-induced excessive inflammation after surgery and significantly improve the symptoms of SIRS.