唐桂毅,刘 妍,张宗鹏.哺乳动物腔前卵泡体外培养的影响因素[J].药物评价研究,2015,38():88-92
哺乳动物腔前卵泡体外培养的影响因素
Factors on in vitro culture of preantral follicles of mammal
投稿时间:2014-11-18  
DOI:
中文关键词:  哺乳动物;腔前卵泡;体外培养;生殖毒理;新药评价
英文关键词:mammal; preantral follicles; in vitro culture; reproductive toxicology; new drug evaluation
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唐桂毅,刘 妍,张宗鹏 天津市新药评价研究中心 
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中文摘要:
      哺乳动物卵巢有大量的腔前卵泡,其中大部分卵泡不能进行排卵,而卵泡发育和闭锁的调节是一个高度复杂的过程。随着对卵泡生长过程的深入研究,国内外已经建立了多种体外培养方法,而腔前卵泡体外培养已成为现今的研究热点,并将其应用于雌性生殖毒理评价研究当中,为新药评价研究提供了可靠的实验工具。对哺乳动物腔前卵泡的体外培养中的胚胎来源、分离方法、培养条件和添加成分等几个方面进行了阐述,为进一步完善腔前卵泡培养体系提供实验依据。
英文摘要:
      Preantral follicles are of great abundance in mammalian ovaries and the vast majority (> 99.9%) never become ovulatory; Regulation of follicular development and atresia is a complicated process. With further research about the process of follicle growth, many in vitro models have been established at home and abroad, while in vitro culture of preantral follicles that is applied to evaluating female reproductive toxicology and provides a reliable experimental tool for new drug evaluation has become a hot spot in the current study. This paper reviews the various factors in vitro culture of preantral follicles, such as embryos, separation methods, cultural conditions, and additives, which would further achieve the system to provide experimental basis for the culture.
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