刘 巍,徐为人,汤立达.Gab2支架蛋白——新的抗癌药物靶点[J].药物评价研究,2014,37():
Gab2支架蛋白——新的抗癌药物靶点
Gab2 scaffolding protein as a new therapeutic target in cancer
  
DOI:
中文关键词:  支架蛋白;Gab2;信号通路;癌症;靶点
英文关键词:scaffolding protein; Gab2; signaling pathway; cancer; target
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作者单位
刘 巍,徐为人,汤立达 天津药物研究院,天津市新药设计与发现重点实验室,天津 300193 
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中文摘要:
      接头蛋白或支架蛋白可以介导蛋白-蛋白之间的相互作用,并促进蛋白复合物的形成。Gab2作为中介分子,通过招募受体酪氨酸激酶等膜受体与其下游的效应蛋白如SHP2、P13K的p85亚基,PLCγ、CRK、SHC和SHIP的结合来实现信号的传递。近年来,由于Gab2支架蛋白在信号转导过程中发挥着重要的作用,使得其在人类癌症特别是白血病、乳腺癌、卵巢癌及黑色素瘤中的角色备受关注。Gab2主要参与介导SHP2/RAS/ERK和PI3K/AKT两条经典的信号通路。综述Gab2的结构与功能,调解的蛋白,在癌症中的作用以及其作为药物治疗靶点的潜力。
英文摘要:
      Adaptor or scaffolding proteins mediate protein-protein interactions that drive the formation of protein complexes. Gab2 scaffolding protein is an intermediary molecule that links plasma membrane receptor signaling including receptor tyrosine kinases with the downstream effectors such as SHP2, p85 subunit of PI3K, PLCγ, CRK, SHC, and SHIP. Although well described in signal transduction, the role of Gab2 scaffolding protein in cancer has recently been emerging especially in leukemia, breast and ovarian cancer, and melanoma. Gab2 is essential for mediating the two major signal transduction pathways in cancer, the PI3K-AKT and ERK signaling pathways. This review focuses on the structure and function of Gab2, its regulatory proteins, emerging role in cancer, and potential as a therapeutic target.
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