脑胶质瘤作为威胁人类健康的癌症之一，是中枢神经系统最常见和最具有侵袭性的原发性恶性肿瘤。目前，现代医学针对脑胶质瘤患者主要以手术切除为主，并结合化疗、靶向治疗及免疫治疗等延长患者的生存时间，但由于术后复发率、致残率和病死率高，以及化疗药物靶向不确切，长期用药易产生多药耐药等问题，从而使脑胶质瘤的治疗难以取得理想疗效。近年来，天然产物抗脑胶质瘤为其治疗的发展提供新的思路。研究表明，天然产物对多种恶性肿瘤具有化学学预防和抗肿瘤活性，其直接或间接（靶向MAPK/Erk1/2、PI3K/Akt/NF-κB和NF-κB等信号通路）调控脑胶质瘤免疫细胞、抑制肿瘤血管生成、诱导氧化应激、细胞凋亡、增殖与侵袭、细胞周期阻滞及逆转细胞耐药以发挥其抗脑胶质瘤作用。从天然产物抗脑胶质瘤发挥作用机制出发，总结其抗肿瘤作用的研究成果，以期为脑胶质瘤治疗提供新的研究思路，从而推动中医药现代化的发展进程。

As one of the cancers threatening human health, brain glioma is the most common and aggressive primary malignant tumor of the central nervous system. At present, modern medicine mainly focuses on surgical resection for glioma patients, and combines chemotherapy, targeted therapy and immunotherapy to prolong the survival time of patients. However, due to the high recurrence rate, disability rate and mortality rate after surgery, as well as the inaccurate targeting of chemotherapy drugs, long-term drug use is easy to produce multi-drug resistance and other issues, so that the treatment of glioma is difficult to achieve ideal efficacy. In recent years, natural products against glioma have provided new ideas for the development of its treatment. Studies have shown that natural products have chemical preventive and antitumor activities on a variety of malignant tumors. It directly or indirectly (targeting MAPK /Erk1/2, PI3K/Akt/NF-κB and NF-κB signaling pathways) regulates glioma immune cells, inhibits tumor angiogenesis, induces oxidative stress, cell apoptosis, proliferation and invasion, cell cycle arrest and reverses cell resistance to exert its anti-glioma effect. Based on the mechanism of anti-tumor effects of natural products on brain glioma, this paper summarizes the research results of anti-tumor effects of natural products in order to provide new research ideas for brain glial therapy and promote the modernization of traditional Chinese medicine.

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国家自然科学基金资助项目（82204981）； 河南省特色骨干学科中医学学科建设项目（STG-ZYX06-202145）；河南省中医药科学研究专项课题（2021JDZX2002）；河南省中医药科学研究专项课题（2024ZY2061）； 河南省中医药科学研究专项课题（2024ZY2061）；河南省中医院博士科研基金（2022BSJJ07）；河南省中医院博士科研基金（2023BSJJ02）；河南中医药大学 2023 年度研究生科研创新能力提升计划项目（2023KYCX043）；河南中医药大学 2023 年度研究生科研创新能力提升计划项目（2023KYCX051）