目的 通过对近5年中药抗癌相关研究的文献分析，探析中药抗癌研究领域的相关热点与前沿。方法 以Web ofScience（WOS）、中国学术期刊全文数据库（CNKI）以及维普生物医学数据库（VIP）等国内外数据库为数据源，运用CiteSpace、Note Express等软件对所筛选文献的年度发文量、作者、机构、关键词等方面进行分析，绘制可视化图谱，并分析目前中药抗癌领域的研究热点及趋势。结果 中药抗癌领域文献以英文文献为主，各文献大多为中国各省中医药大学等研究机构发表；综合分析，各国学者较多采用网络药理学预测加细胞和动物药理实验验证的方式对中药抗癌进行研究，目前治疗癌症的研究热点药物主要为黄芪和人参、热点活性成分为槲皮素和姜黄素，而最近的研究趋向为小檗碱、六君子汤、EGFR基因和癌症治疗中的不良反应等。结论 中药治疗癌症方面的研究目前仍处于快速发展阶段，目前该领域热点聚焦于中药及中药活性成分开发利用、方剂临床应用、作用机制等方面，但尚存在团队间缺乏大规模合作、研究深度不够等不足。

Objective To analyze the literature on anti-cancer research in traditional Chinese medicine in the past five years, and to explore the relevant hotspots and frontiers in the field of anti-cancer research of traditional Chinese medicine. Methods Web of Science (WOS), China National Knowledge Infrastructure (CNKI) and VIP databases were used as data sources, and Cite Space, Note Express and other software were used to analyze the annual publication volume, authors, institutions, keywords and other aspects of the screened literature, and the visual map was drawn. And analyze the current research hotspots and trends in the field of traditional Chinese medicine anti-cancer. Results The literature in the field of anti-cancer of traditional Chinese medicine was mainly in English, and most of the literature was published by universities of traditional Chinese medicine and other research institutions in various provinces of China. Based on comprehensive analysis, scholars from various countries tend to use network pharmacology predictio combined with cell and animal experimental pharmacology verification to study the anti-cancer effects of traditional Chinese medicine, at present, the research hotspots for the treatment of cancer are mainly Astragali Radix and Ginseng Radix et Rhizoma, and the hot active ingredients are quercetin and curcumin, while the recent research tends to be berberine, Liujunzi decoction, EGFR gene and side effects in cancer treatment. Conclusion The research on the treatment of cancer with traditional Chinese medicine is still in the stage of rapid development, and the current hot spots in this field focus on the development and utilization of traditional Chinese medicine and its active ingredients, the clinical application of formulas, and the mechanism of action, but there are still shortcomings such as lack of large-scale cooperation between teams and insufficient research depth.

R979.1

国家中医药管理局科技项目（ GZY-KJS-2023-030）；河北省自然科学基金项目（ H2023423005）；河北省中医药管理局科研计划项目（2023114、 2020130）；河北中医学院优秀青年基金项目（ YQ2020006）