芍药内酯苷是从芍药Paeonia lactiflora分离出来的单萜糖苷类化合物，是芍药的主要活性成分之一，具有抗抑郁、抗炎、镇痛、抗肿瘤、抗凋亡、抗氧化等药理作用。目前，对芍药内酯苷抗抑郁、抗炎作用研究较多，芍药内酯苷在抗抑郁方面作用显著，可能与调节单胺类神经递质、抑制下丘脑-垂体-肾上腺轴（ HPA轴）亢进、促进脑源性神经营养因子（ BDNF）表达有关，并且其可通过抑制N-甲基-D-天冬氨酸（NMDA）受体发挥快速抗抑郁的作用，具有开发成抗抑郁新药的潜力。其次，芍药内酯苷的抗炎作用可能与抑制核因子κB（NF-κB）和丝裂原活化蛋白激酶（MAPK）信号通路有关，通过抑制NF-κB和MAPK信号通路抑制促炎细胞因子的表达，发挥抗炎作用。通过对芍药内酯苷的药理作用进行综述，为进一步对芍药内酯苷的药物研发及临床应用提供依据。

Albiflorin is a monoterpene glycoside isolated from Paeonia lactiflora, which is one of the main active compounds in P. lactiflora. It has pharmacological effects such as anti-depression, anti-inflammation, analgesia, anti-tumor, anti-apoptosis and antioxidation. At present, there are many studies on the anti-depressant and anti-inflammatory effects of albiflorin. Albiflorin significantly exhibits anti-depressant effect by adjusting the levels of monoamine neurotransmitters, inhibiting the hypothalamicpituitary-adrenal axis (HPA axis) hyperactivity, and promoting the expression of brain-derived neurotrophic factor (BDNF). In addition, albiflorin can exert a rapid anti-depressant effect by inhibiting NMDA receptor. Based on the above evidence, albiflorin has the potential to be developed as a new anti-depressant drug. Secondly, the anti-inflammatory effect of albiflorin may be related to the inhibition of NF-κB and MAPK signaling pathways, which inhibit the expression of pro-inflammatory cytokines and play an anti-inflammatory role. In this paper, the pharmacological effects of albiflorin are reviewed, so as to provide a basis for further drug development and clinical application of albiflorin.

R285.5

现代中药新质生产力科技创新工程专项（24ZXZKSY00050）