[关键词]
[摘要]
中药-药物的相互作用已成为药物毒性研究的热点。许多中药的活性成分或其提取物在体内的药效和毒性与转运体相关,转运体的表达或活性可明显影响中药在体内的药动学和生物活性。其中,基于转运体的马兜铃酸、雷公藤甲素等中药成分的肝、肾毒性的研究十分广泛,而中药对转运体的作用也会对其他药物的代谢产生影响从而发生药物的相互作用。主要基于转运体角度来概述中药毒性及对其他药物代谢的影响,对中药的毒性研究及临床上的合理用药具有指导意义。
[Key word]
[Abstract]
Herbal-drug interacitons has become a hot sopt of drug toxicity researches. The potency and toxicity of many active ingredients or extracts of traditional Chinese medicines (TCMs) in vivo are related to transporters, and the expression of activity of the transporter could significantly affect the pharmacokinetics and biological activity of TCMs in the body. Among them, studies on the hepatorenal toxicity of aristolochic acid, triptolide and other TCMs ingredients based on transporters have been extensive. The effect of TCMs on transporters will also affect the metabolism of other drugs, resulting in drug interactions. This article summarized the toxicities of TCMs and the effects on metabolism of other drugs from the perspective of transporters, which has guiding significance for toxicity study of TCMs and rational drug use in clinical practice.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81503347,81503068);国家十三五“重大新药创制”专项(2018ZX09201017)