[关键词]
[摘要]
目的 系统评价戊乙奎醚预防剖宫产术应用卡前列素氨丁三醇所引发的不良反应。方法 计算机检索PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、维普中文期刊全文数据库(VIP)和万方数据库,检索时限均为建库起至2020年5月,收集戊乙奎醚降低卡前列素氨丁三醇在剖宫产术中不良反应的随机对照研究(RCT),采用RevMan 5.3统计软件对恶心、呕吐、面部潮红、胸闷气短、心悸、腹痛及血压升高等不良反应发生率进行Meta分析。结果 共纳入13个RCTs,1 027例患者。Meta分析结果显示:戊乙奎醚组恶心发生率[RR=0.36,95% CI=0.29~0.45,P<0.01]、呕吐发生率[RR=0.21,95% CI=0.15~0.30,P<0.01]、面部潮红发生率[RR=0.37,95% CI=0.26~0.52,P<0.01]、胸闷气短发生率[RR=0.32,95% CI=0.26~0.40,P<0.01]、心悸发生率[RR=0.38,95% CI=0.28~0.50,P<0.01]、腹痛发生率[RR=0.52,95% CI=0.35~0.76,P<0.01]和血压升高发生率[RR=0.43,95% CI=0.22~0.85,P=0.02]均显著低于对照组。结论 戊乙奎醚能显著降低卡前列素氨丁三醇致恶心、呕吐、面部潮红、胸闷气短、心悸、腹痛及血压升高等不良反应的发生。
[Key word]
[Abstract]
Objective To systematically evaluate penehyclidine to reduce the adverse effects of carprostamine trometamol during cesarean section. Methods Retrieved from PubMed, Embase, Cochrane library, CBM, CNKI, VIP and Wanfang database, randomized controlled trials (RCTs) about the penehyclidine to reduce the adverse effects of carprostamine trometamol during cesarean section were collected during database establishment to May 2020. Meta-analysis was performed for the incidence of nausea, vomiting, facial flushing, chest tightness, shortness of breath, palpitations, abdominal pain and increased blood pressure by using Rev Man 5.3 statistical software. Results A total of 13 RCTs were included, involving 1 027 patients. Meta-analysis showed that the penehyclidine group in the incidence of nausea in[RR=0.36, 95%CI=0.29 to 0.45, P<0.01], the incidence of vomiting[RR=0.21, 95%CI=0.15 to 0.30, P<0.01], the incidence of facial flushing[RR=0.37, 95%CI=0.26 to 0.52, P<0.01], incidence of chest tightness[RR=0.32, 95%CI=0.26 to 0.40, P<0.01], incidence of heart palpitations[RR=0.38, 95%CI=0.28 to 0.50, P<0.01], incidence of abdominal pain[RR=0.52, 95%CI=0.35 to 0.76, P<0.01] and incidence of high blood pressure[RR=0.43, 95%CI=0.22 to 0.85, P=0.02] significantly lower than the control group. Conclusion The results of this study shows that penehyclidine can significantly reduce the incidence of nausea, vomiting, facial flushing, chest tightness, palpitations, abdominal pain and increased blood pressure caused by carprostamine trometamol.
[中图分类号]
R984
[基金项目]
河北省科技计划资助项目(172777108D)