[关键词]
[摘要]
目的 探讨归芪活血胶囊联合硫酸氨基葡萄糖治疗关节镜术后膝关节骨性关节炎的临床疗效。方法 选取日照市人民医院骨科门诊于2016年6月-2018年8月收治的84例膝关节骨性关节炎患者作为研究对象,根据治疗方法的不同随机分为对照组和观察组,每组各42例。对照组口服硫酸氨基葡萄糖胶囊,2粒/次,3次/d。观察组在对照组基础上口服归芪活血胶囊,3粒/次,3次/d。两组均连续服用1个月。观察两组患者的临床疗效,同时比较两组治疗前后的中医证候积分、疼痛评分、肿胀评分及关节活动度。结果 治疗后,对照组总有效率83.3%,显著低于观察组的92.9%,两组对比差异具有统计学意义(P<0.05)。治疗后,两组各中医证候积分较治疗前明显下降(P<0.05);且治疗后,观察组各中医证候积分均显著低于对照组(P<0.05)。治疗后,疼痛评分和肿胀评分较治疗前下降明显,关节活动度显著升高(P<0.05);治疗后,观察组疼痛评分和肿胀评分显著低于对照组,关节活动度显著高于对照组(P<0.05)。结论 归芪活血胶囊联合硫酸氨基葡萄糖治疗膝关节骨性关节炎患者疗效显著,可减轻患者疼痛、肿胀感,有利于患者膝关节功能恢复。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Guiqi Huoxue Capsules combined with glucosamine sulfate in treatment of knee osteoarthritis after arthroscopy. Methods A total of 84 patients with knee osteoarthritis admitted to Rizhao People's Hospital from June 2016 to August 2018 were selected as the research subjects. According to different treatment methods, they were randomly divided into control group and observation group, with 42 patients in each group. Patients in the control group were po administered with Glucosamine Sulfate Capsules, 2 capsules/time, three times daily. Patients in the observation group were po administered with Guiqi Huoxue Capsules on the basis of control group, 3 grains/time, three times daily. Both groups were treated for 1 month. The clinical efficacy of two groups was observed, and the TCM syndrome score, pain score, swelling score and range of motion were compared before and after treatment. Results After treatment, the total effective rate of the control group was 83.3%, which was significantly lower than 92.9% of the observation group, and the difference between two groups was statistically significant (P<0.05). After treatment, the TCM syndrome scores of two groups were significantly lower than those before treatment (P<0.05); After treatment, the TCM syndrome scores of the observation group were significantly lower than those of the control group (P<0.05). After treatment, the pain score and swelling score decreased significantly, and the range of motion were increased (P<0.05). After treatment, the pain score and swelling score in the observation group were significantly lower than those in the control group, but the range of motion in the observation group was significantly higher than that in the control group (P<0.05). Conclusion Guiqi Huoxue Capsules combined with glucosamine sulfate has a significant effect in treatment of patients with knee joint osteoarthritis, which can reduce the pain and swelling of patients, and is conducive to the recovery of the function of patients with knee joint.
[中图分类号]
R982
[基金项目]
国家重点研发计划项目(2019YFC1711200)