[关键词]
[摘要]
细胞治疗作为新兴的现代生物医学技术,促进了以精准医学和系统生物学为代表的治疗变革,也不断地与中医关于生命认识的整体观和"天人合一"的思维接近。细胞治疗为肿瘤等多种疾病的治疗提供了新的策略,但其不良反应和应用局限制约了其在临床上的广泛应用。中医药与细胞治疗联合使用,发挥协同作用,在提高细胞治疗疗效、减轻毒副作用方面已经做了一些探索和尝试。概述中医药在免疫细胞治疗、干细胞治疗和基因修饰体细胞治疗中的应用现状,初步探讨中医药联合细胞治疗在未来的发展趋势。
[Key word]
[Abstract]
As an emerging modern biomedical technology, cell therapy has promoted the therapeutic revolution represented by precision medicine and systematic biology, and is also close to the concept of the holistic view of life understanding and "harmony between man and nature" in traditional Chinese medicine. Cell therapy provides a new strategy for the treatment of many diseases such as tumors, but its adverse reactions and application limitations restrict its wide application in clinic. Combined use of traditional Chinese medicine and cell therapy plays a synergistic role, and some explorations and attempts have been made to improve the efficacy of cell therapy and reduce the toxic and side effects. This paper summarizes the application of TCM in immune cell therapy, stem cell therapy and genetically modified somatic cell therapy, and discusses the development trend of TCM combined cell therapy in the future.
[中图分类号]
R926
[基金项目]
国家科技重大专项课题——重大新药创制(2016ZX09101094);北京市科委企业技术创新平台建设(Z181100000518028)