[关键词]
[摘要]
脂质是机体内重要的营养物质之一,参与机体的能量供应、生物膜形成以及代谢调节等,内质网是其合成的主要场所。近年来越来越多研究表明,细胞色素P450酶的表达和活性影响机体对有害物质的敏感性以及药物的疗效,影响疾病的发生及发展,而细胞色素P450酶作为膜蛋白受到膜组成的影响。就细胞色素P450酶调控过程中内质网脂质稳态的作用进行综述。
[Key word]
[Abstract]
Lipid is one of the important nutrients in the body. It is involved in energy supply, formation of biomembrane and metabolic regulation. Endoplasmic reticulum is the main site for enzyme synthesis. In recent years, more and more reports have shown that the expression and activity of P450s affect the body's sensitivity to harmful substances and the efficacy of drugs, which affects the occurrence and development of diseases. Metabolic enzymes are membrane proteins so that they can be affected by the composition of membrane. In this review, we summarized the function of endoplasmic lipid homeostasis in P450s regulation.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(81872932)