[关键词]
[摘要]
目的 研究注射用丹参多酚酸对急性脑梗死患者神经功能、血小板平均体积(MPV)和血小板平均体积/淋巴细胞计数(MPVLR)的影响。方法 选取2017年12月-2019年12月于漯河市中心医院住院治疗的急性脑梗死非重症患者110例为研究对象,用随机数字表法将患者分为对照组和观察组,每组各55例。对照组给予常规治疗;观察组在对照组的基础上将活血化瘀类药物替换为注射用丹参多酚酸,0.13 g配伍0.9%氯化钠溶液250 mL静脉注射,1次/d。两组患者疗程为2周。比较两组患者治疗前后的美国国立卫生研究院卒中量表评分(NIHSS)、巴氏(Balthel)指数评分、MPV和MPVLR水平。结果 治疗后,两组NIHSS评分均显著下降,Barthel指数评分显著上升,同组治疗前后对比差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分显著低于对照组,Barthel指数评分明显高于对照组,两组间对比差异有统计学意义(P<0.05)。治疗后,两组MPV、MPVLR显著降低,同组治疗前后对比差异有统计学意义(P<0.05);治疗后,且观察组MPV、MPVLR水平明显低于对照组,两组间对比差异有统计学意义(P<0.05)。结论 注射用丹参多酚酸能够改善急性脑梗死患者神经功能,降低患者MPV、MPVLR水平,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the effects of Salvianolic Acids for Injection on neurological function, MPV, and MPVLR in patients with acute cerebral infarction. Methods A total of 110 patients with acute cerebral infarction in Luohe Central Hospital from December 2017 to December 2019 were selected as the research objects. The patients were randomly divided into control group and observation group, with 55 cases in each group. Patients in the control group were given routine treatment. Patients in the observation group, the drugs of promoting blood circulation and removing blood stasis were replaced by Salvianolic Acids for Injection on the basisi of control group, patients were iv administered with Salvianolate for injection, 0.13 g was combined with 0.9% sodium chloride solution 250 mL, once daily. The course of treatment in two groups was 2 weeks. After treatment, the NIHSS, Barthel index, the levels of MPV and MPVLR before and after treatment were compared between two groups. After treatment, NIHSS scores of two groups were significantly decreased, Barthel Index scores were significantly increased, the difference was statistically significant in the same group before and after treatment (P<0.05). Results After treatment, NIHSS score of observation group was significantly lower than that of control group, Barthel index score was significantly higher than that of control group, the difference between the two groups was statistically significant (P<0.05). After treatment, MPV and MPVLR of two groups were significantly decreased, and the difference was statistically significant in the same group before and after treatment (P<0.05). After treatment, the MPV and MPVLR levels in the observation group were significantly lower than those in the control group, and the difference between the two groups was statistically significant (P<0.05). Conclusion Salvianolic Acids for Injection can improve the neurological function of patients with acute cerebral infarction, and reduce the level of MPV and MPVLR, which has certain clinical application value.
[中图分类号]
R971
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