[关键词]
[摘要]
目的 探讨注射用丹参多酚酸联合阿托伐他汀治疗急性脑梗死的临床疗效,及对氧化型低密度脂蛋白(ox-LDL)和心型脂肪酸结合蛋白(H-FABP)影响。方法 选择2017年6月-2018年12月鹤壁煤业(集团)有限责任公司总医院收治的脑梗塞急性期患者86例作为研究对象,采用随机数字表法随机分为对照组(n=43)和观察组(n=43)。对照组口服阿托伐他汀钙片,20 mg/次,1次/d。观察组在对照组治疗的基础上静脉滴注注射用丹参多酚酸,100 mg加入250 mL生理盐水中,1次/d。两组疗程均为14 d。观察两组患者的临床疗效,同时比较两组患者治疗前后的凝血功能、炎症介质、ox-LDL和H-FABP水平。结果 治疗后,观察组总有效率为93.02%,显著高于对照组的72.09%(P<0.05)。治疗后,两组患者纤维蛋白原(Fib)和D-二聚体指标均显著降低(P<0.05);治疗后,观察组患者Fib和D-二聚体指标低于对照组(P<0.05)。治疗后,两组白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)和基质金属蛋白酶-9(MMP-9)水平均显著降低(P<0.05);治疗后,观察组患者IL-18、TNF-α和MMP-9水平显著低于对照组(P<0.05)。治疗后,两组患者ox-LDL和HFABP水平均显著降低(P<0.05);治疗后,观察组患者ox-LDL和H-FABP水平显著低于对照组(P<0.05)。结论 注射用丹参多酚酸联合阿托伐他汀治疗急性脑梗死患者的疗效明显,可改善患者凝血功能,减轻炎症反应,降低ox-LDL和HFABP水平,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Salvianolic Acids for Injection combined with atorvastatin in treatment of acute cerebral infarction and its effect on ox-LDL and H-FABP. Methods A total of 86 patients with acute cerebral infarction admitted to General Hospital of Hebi Coal Industry (Group) Co., Ltd from June 2017 to December 2018 were selected as study subjects. Patients were randomly divided into control group (n=43) and observation group (n=43) by random number table method. Patients in the control group po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the observation group were iv adminintered with Salvianolic Acids for Injection on the basis of control group, 100 mg was added to 250 mL normal saline, once daily. The course of treatment in both groups was 14 d. The clinical efficacy in two groups of patients was observed, and the coagulation function, inflammatory mediators, ox-LDL and H-FABP levels in two groups before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 93.02%, significantly higher than 72.09% in the control group (P<0.05). After treatment, the levels of Fib and D-dimer indexes in two groups were significantly decreased (P<0.05). After treatment, the levels of Fib and D-dimer indexes in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IL-18, TNF-α, and MMP-9 in two groups were significantly decreased (P<0.05). After treatment, the levels of IL-18, TNF-α, and MMP-9 in the observation group were significantly lower than those in the control group (P<0.05). After treatment, ox-LDL and H-FABP levels in both groups were significantly decreased (P<0.05). After treatment, ox-LDL and H-FABP levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Salvianolic Acids for Injection combined with atorvastatin in treatment of patients with acute cerebral infarction has obvious curative effect, which can improve patients' blood coagulation function, reduce the inflammatory response, and ox-LDL and H-FABP levels, which has a certain clinical application value.
[中图分类号]
R971
[基金项目]