[关键词]
[摘要]
目的 观察注射用丹参多酚酸治疗恢复期脑干梗死的疗效与安全性。方法 收集驻马店市中心医院2017年1月-2019年12月收治的恢复期脑干梗死住院患者80例,随机分为对照组及观察组,每组40例。对照组给予抗血小板聚集、降脂等治疗,观察组在对照组基础上加用注射用丹参多酚酸0.13 g+0.9%氯化钠注射液250 mL,静脉滴注,1次/d,两组均治疗14 d。比较两组患者美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(Bathel指数)评分、疗效及不良反应。结果 治疗前两组患者的NIHSS评分、日常生活能力评分无统计学差异。治疗后,两组NIHSS评分均低于治疗前(P<0.05),且观察组低于对照组(P<0.05);两组日常生活能力评分均较治疗前提高(P<0.05),且观察组较对照组明显提高(P<0.05);观察组总有效率95.00%,明显高于对照组的82.50%(P<0.05)。两组未见明显的不良反应。结论 注射用丹参多酚酸治疗恢复期脑干梗死效果良好,可提高总有效率,且用药安全。
[Key word]
[Abstract]
Objective To observe the clinical efficacy and safety of Salvianolic Acid for Injection in treatment of convalescent brainstem infarction. Methods A total of 80 convalescent patients with convalescent brainstem infarction in Zhumadian Central Hospital from January 2017 to December 2019 were selected and divided randomly into control group and observation group, 40 patients in each group. The control group was given anti-platelet aggregation, lipid-lowering treatment, etc. The observation group was added to the control group with Salvianolic Acid for Injection 0.13g + 0.9% sodium chloride injection 250 mL, intravenous drip, once per day, both groups were treated for 14 days. The national Institutes of Health Stroke Scale (NIHSS) score, daily life ability (Bathel Index) score, treatment effect and adverse reactions were compared between two groups. Results There were no statistical difference in NIHSS score and Bathel Index between two groups before treatment. After treatment, NIHSS scores in both groups were lower than those before treatment (P<0.05), and NIHSS scores in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). The Bathel Index of both groups was improved compared with that before treatment (P<0.05), and was significantly improved in the observation group compared with the control group (P<0.05). The cure rate of 95.00% in the observation group was significantly higher than 82.50% in the control group (P<0.05). There was no adverse reactions in two groups. Conclusion Salvianolic acid for Injection in the treatment of convalescent brainstem infarction is effective, can improve the cure rate, and it is safety.
[中图分类号]
R285.6;R286.1
[基金项目]