[关键词]
[摘要]
目的 注射用益气复脉(冻干)联合左西孟旦对慢性心力衰竭患者心功能、血流动力学和炎性因子的影响。方法 选取2018年10月-2019年10月聊城市中医医院收治的慢性心力衰竭住院患者100例为研究对象,将患者按入组顺序进行编号分为对照组和观察组,每组各50例。对照组给予左西孟旦注射液治疗,设定初始负荷剂量为12 μg/kg,持续注射10 min;之后以0.1 μg/(kg·min)剂量静脉滴注,1 h后将滴注剂量增至0.2 μg/(kg·min)并持续滴注23 h。观察组在对照组治疗基础上静脉滴注注射用益气复脉(冻干),1.3 g药液溶至5%葡萄糖注射液250 mL中,1次/d,连续治疗14 d。比较两组患者治疗前后的心功能指标、血流动力学和炎性因子水平。结果 治疗后,两组脑钠肽(BNP)水平均显著降低,每搏心输出量(SV)、左室射血分数(LVEF)及6 min步行试验距离均显著升高(P<0.05);且观察组患者BNP显著低于对照组,SV、LVEF及6 min步行试验距离显高于对照组(P<0.05)。治疗后,两组心率(HR)、收缩压(SBP)及舒张压(DBP)均显著降低(P<0.05);观察组患者HR显著低于对照组,SBP、DBP显著高于对照组(P<0.05)。治疗后,两组血浆超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白介素-6(IL-6)水平均显著降低(P<0.05);观察组患者血浆hsCRP、TNF-α及IL-6水平显著低于对照组(P<0.05)。结论 采用注射用益气复脉(冻干)联合左西孟旦治疗慢性心力衰竭,可显著改善心功能和血流动力学指标,抑制全身炎症反应,其效果优于单纯左西孟旦治疗。
[Key word]
[Abstract]
Objective Effects of injection of Yiqi Fumai Lyophilized Injection combined with levosimendan on cardiac function, hemodynamics and inflammatory factors in patients with chronic heart failure. Methods A total of 100 patients with chronic heart failure admitted to Liaocheng Traditional Chinese Medicine Hospital from October 2018 to October 2019 were selected as the research objects, and the patients were numbered according to the inclusion sequence and divided into the control group and the observation group, with 50 patients in each group. Patients in the control group was given Levosimendan Injection, the initial loading dose was set as 12 μg/kg lasted for 10 min. After intravenous infusion at 0.1 μg/(kg·min) for 1 h, the infusion dose was increased to 0.2 μg/(kg·min) and continued for 23 h. Patients in the observation group were iv administered with Yiqi Fumai Lyophilized Injection on the basisi of control group, 1.3 g was dissolved into 5% glucose injection 250 mL, once daily, and the treatment lasted for 14 d. After treatment, the levels of cardiac function, hemodynamics and inflammatory factors before and after treatment were compared between two groups. Results After treatment, the levels of BNP were significantly decreased in two groups, but the SV, LVEF, and the 6 min walking distance were significantly increased (P<0.05). And BNP in the observation group was significantly lower than that in the control group, SV, LVEF and the 6 min walking distance were significantly higher than those in the control group (P<0.05). After treatment, HR, SBP, and DBP were significantly decreased in two groups (P<0.05). HR in the observation group was significantly lower than that in the control group, SBP and DBP were significantly higher than those in the control group (P<0.05). After treatment, plasma hs-CRP, TNF-α, and IL-6 levels in two groups were significantly decreased (P<0.05). The plasma hs-CRP, TNF-α, and IL-6 levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Yiqi Fumai Lyophilized Injection combined with levosimendan in treatment of patients with chronic heart failure can significantly improve the cardiac function and hemodynamic indicators, and inhibit systemic inflammatory response. The effect is better than that of levosimendan alone.
[中图分类号]
R972
[基金项目]