[关键词]
[摘要]
中药复方作为中医临床用药最广泛的形式,其药效物质基础和作用机制的科学阐释成为全面揭示中医药实用价值进而实现中药现代化的关键。代谢组学技术始于20世纪90年代中期,旨在利用现代科学技术研究生物体系在受到刺激或干扰后,内源性代谢物组的变化或随时间的变化规律,以代谢物组分析为基础,借助高通量检测和多元化数据处理手段,整合多维生物信息系统,阐明中药复方的药效物质基础和作用机制。综述了最新代谢组学技术的研究进展及在中药复方药效物质基础和作用机制研究中的应用情况,并对代谢组学技术未来发展趋势进行展望。
[Key word]
[Abstract]
Traditional Chinese medicine(TCM) prescriptions is the most extensive form in clinical parctice for traditional Chinese medicine, and its effective substances and mechanism is key to achieve modernization and comprehensively reveal the essence of traditional Chinese medicine theory. Metabolomics began in the mid-1990s with the aim of using modern science and technology to probe into the endogenous metabolites changes and time-dependent discipline after stimulation or interference in biological systems. It clarifies effective substances and mechanism based on metabolite analysis, high-throughput detection, diversity data processing andsystematic information integration. In this paper, we reviewed metabolomics technology development in recent years and its application in effective substances and mechanism of TCM prescriptions research. Meanwhile, modernization research and the future trend were also discussed.
[中图分类号]
[基金项目]
国家重大科技专项重大新药创制——中医药优势领域的创新中药关键技术开发研究(2017ZX09301005