[关键词]
[摘要]
瞬时受体电位4型(TRPV4)是一种非选择性钙离子渗透性通道,通过对细胞内Ca2+的调节在许多生理和病理过程中发挥重要作用,其功能异常或缺失会引起多种疾病。功能性TRPV4在人前脂肪细胞(即脂肪细胞前体细胞)中特别丰富,通过对细胞内Ca2+的调节,在脂肪的合成、分解和调节脂质稳态过程中发挥重要作用。TRPV4还能有效地控制多种促炎基因的表达,参与胰岛素抵抗的发展,并提供对高脂肪饮食引起肥胖的保护,可能是药理学干预肥胖及相关代谢性疾病的一个非常重要的靶点。对TRPV4与脂肪代谢的关系做一综述。
[Key word]
[Abstract]
Transient receptor potential type 4 (TRPV4) is a calcium-permeable non-selective cation channel that plays an important role in many physiological and pathological processes through the regulation of intracellular Ca2+. Abnormal or absent function of TRPV4 can cause a variety of diseases. Functional TRPV4 is particularly abundant in human preadipocytes (ie, adipocyte precursor cells), which plays an important role in the synthesis, decomposition and regulation of lipid homeostasis by regulating intracellular Ca2+. Deletion of TRPV4 alters energy metabolism through an increase in calcineurin activity, leading to increased energy expenditure and providing protection against obesity caused by a high-fat diet, which may be a very important target for therapeutic pharmacological intervention. This paper reviews the relationship between TRPV4 and fat metabolism.
[中图分类号]
[基金项目]
山西省自然基金一般项目(201601D102062)