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[摘要]
冠心病是威胁人类健康的主要疾病之一,其患病率及死亡率逐年上升。依折麦布作为一种胆固醇肠吸收抑制剂,通过改善血脂水平、抑制炎症反应、缩小或逆转斑块,发挥抗动脉粥样硬化作用,延缓冠心病的发生和进展,并抑制炎性反应,改善血管内皮功能,从而减少临床终点事件的发生,提升患者疗效及预后水平。对依折麦布治疗冠心病的作用机制及临床疗效的研究进展进行综述。
[Key word]
[Abstract]
Coronary heart disease is one of the major diseases that threaten human health, and its prevalence and mortality increase year by year. Coronary heart disease is the most common type of organ lesion caused by atherosclerosis. As a cholesterol intestinal absorption inhibitor, by improving blood lipid levels, inhibiting inflammatory reactions, reducing or reversing plaque, play an antiatherosclerotic effect, thus delaying the occurrence and development of coronary heart disease, and inhibit inflammatory reactions, improve vascular endothelial function, thereby reducing the occurrence of clinical endpoints, improve the efficacy and prognosis of patients. A review of the research progress on the mechanism of action and clinical therapeutic effect of ezetimibe in the treatment of coronary heart disease.
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