目的 探讨血必净注射液对脓毒性休克患者血管内皮功能相关因子的表达影响。方法 选择2014年9月—2018年12月在连云港市第二人民医院ICU诊治的脓毒性休克患者104例，根据随机数字表法分为观察组与对照组，各52例，对照组给予常规药物治疗，观察组在对照组治疗的基础上给予血必净注射液治疗，记录内皮细胞特异性分子-1（ESM-1）表达变化情况，同时测定肾功能相关指标，包括血肌酐（Scr）、尿素氮（BUN），记录两组患者治疗后28 d的APACHEⅡ评分与死亡情况。结果 治疗后观察组与对照组的血清BUN、Scr、ESM-1都显著低于治疗前（P<0.05），观察组也显著低于对照组（P<0.05）。治疗后两组的白细胞计数都显著高于治疗前（P<0.05），且观察组高于对照组（P<0.05）。观察组治疗后28 d的APACHEⅡ评分显著高于对照组（P<0.05），死亡率也低于对照组（P<0.05）。结论 血必净在脓毒性休克患者中的应用能抑制ESM-1的表达，提高白细胞水平，从而改善患者的肾功能，降低患者的死亡率。

Objective To investigate the effects of Xuebijing Injection on the expression of vascular endothelial function-related factors in patients with septic shock.Methods From September 2014 to December 2018, 104 patients with septic shock who were treated in the ICU of our hospital were enrolled and were equally divided into the Xuebijing group and control group accorded to the random number table method. The control group were given conventional medication treatment, and the Xuebijing group were given Xuebijing Injection treatment based on the treatment of the control group, and the expression of endothelial cell specific molecule-1 (ESM-1) were recorded. Results After treatment, serum BUN, Scr and ESM-1 levels in Xuebijing group and control group were significantly lower than before treatment (P<0.05), and Xuebijing group were also significantly lower than control group (P<0.05). The white blood cell counts of the two groups were significantly higher than those before treatment (P<0.05), and the Xuebijing group was higher than the control group (P<0.05). The APACHE II score at 28 days after treatment in Xuebijing group were significantly higher than that in the control group (P<0.05), and the mortality were lower than that in the control group (P<0.05). Conclusion The application of Xuebijing Injection in patients with septic shock can inhibit the expression of ESM-1 and increase the level of white blood cells, thereby improving renal function and reducing mortality.

江苏省自然科学基金资助项目（BK20151107）