[关键词]
[摘要]
目的 探讨氟哌噻吨美利曲辛片联合西沙必利片对胃肠功能紊乱患者负性情绪及血生化指标的影响。方法 选取2016年1月—2017年11月连云港市第一人民医院70例胃肠功能紊乱患者作为研究对象,根据随机抽签原则将受试者分为对照组和观察组,每组各35例。对照组口服西沙必利片治疗,5 mg/次,3次/d;观察组在对照组的基础上联合氟哌噻吨美利曲辛片治疗,1片/次,2次/d。两组均连续治疗1个月。比较两组的临床疗效、治疗前后各负面情绪评分及各血生化指标水平变化以及不良反应发生情况。结果 治疗后,观察组的总有效率显著高于对照组(P<0.05)。治疗后,两组的焦虑、抑郁评分较治疗前均明显下降(P<0.05),且观察组显著低于对照组(P<0.05)。治疗前后两组的尿素氮(BUN)、血清中肌酐(Cr)、丙氨酸氨基转移酶(ALT)及肌酸激酶(CK)等血生化指标水平比较无统计学差异,治疗期间两组均未发生明显的不良反应。结论 西沙必片利联合氟哌噻吨美利曲辛片可有效改善患者的临床症状及负性情绪,且不影响血生化指标水平,疗效安全显著,在胃肠功能紊乱患者治疗中具有积极意义。
[Key word]
[Abstract]
Objective To explore effect of Cisapride Tablets combined with Flupentixol and Melitracen Tablets on negative emotion and blood biochemical parameters in patients with gastrointestinal disorders. Methods A total of 70 patients with gastrointestinal disorders were selected as the subjects from January 2016 to November 2017. According to the principle of random lottery, all patients were divided into control group and study group with 35 cases in each group. The control group were treated with Cisapride Tablets, 5 mg/time, three times daily. The observation group were treated with Flupentixol and Melitracen Tablets on the basis of control group, 1 tablet/time, twice daily. Patients in two groups were treated continuously for 1 month. Clinical efficacy, negative emotion scores, changes in blood biochemical indicators, and the incidence of adverse reactions before and after treatment were compared between two groups. Results After treatment, the total effective rate in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the anxiety and depression scores of the two groups were significantly lower than before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). There were no significant differences in blood biochemical indicators of the BUN, Cr, ALT and CK between two groups before and after treatment. No obvious adverse reactions occurred in two groups during the treatment. Conclusion Cisapride Tablets combined with Flupentixol and Melitracen Tablets can effectively improve clinical symptoms and negative emotions, and do not affect the level of blood biochemical indicators, the efficacy is safe and significant, which has positive significance in the treatment of patients with gastrointestinal disorders.
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[基金项目]
江苏省卫生计生委课题(BJ16009)