液质联用技术以其高分离能力、高分辨率和专属性强的优势，在药物分析等方面得到广泛的应用。主要从串联四极杆质谱仪、四极离子阱质谱仪、四极杆-飞行时间质谱仪方面总结近年来液质联用技术在药物有关物质分析方面的应用。

Liquid chromatography-mass spectrometry is regarded as an important technology for many advantages such as high separating efficiency, good sensitivity, and strong specificity. So it is widely used in analysis of drugs and metabolites, chemical medicine mixed illegally in Chinese medicine and drug residues. This paper briefly reviewed its application in drug related substances analysis from Quadrupole Mass Spectrometer, Quadrupole Ion Trap Mass Spectrometer, and Quadrupole-Time of Flight Mass Spectrometer.