目的 探讨猴头菌提取物颗粒联合美沙拉秦肠溶片治疗溃疡性结肠炎的临床疗效。方法 选取2016年4月—2018年4月咸阳市第一人民医院收治的120例溃疡性结肠炎患者作为研究对象，将所有患者根据随机数字表法分为对照组和治疗组，每组各60例。对照组患者口服美沙拉秦肠溶片，1片/次，3次/d；治疗组患者在对照组治疗的基础上口服猴头菌提取物颗粒，3 g/次，3次/d。两组患者均持续治疗4周。观察两组的临床疗效，比较两组的血清炎性因子水平、疾病活动指数（DAI）评分、临床症状改善时间。结果 治疗后，对照组和治疗组的总有效率分别为81.67%、95.00%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组血清炎性因子水平明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者DAI评分显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组DAI评分明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患者治愈时间、黏液脓血便消失时间均短于对照组，两组比较差异有统计学意义（P<0.05）。结论 猴头菌提取物颗粒联合美沙拉秦肠溶片治疗溃疡性结肠炎具有较好的治疗效果，可改善患者临床症状，降低血清炎性因子水平，具有一定临床推广应用价值。

Objective To investigate the curative effect of Hedgehog Fungus Extract Granules combined with Mesalazine Enteric-Coated Tablets in treatment of ulcerative colitis. Methods Patients (120 cases) with ulcerative colitis in the First People's Hospital of Xianyang from April 2016 to April 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Mesalazine Enteric-Coated Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Hedgehog Fungus Extract Granules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the serum levels of inflammatory factors, DAI scores, and the improvement time of clinical symptoms in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.67% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of IL-8, TNF-α and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the DAI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the DAI scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the cure time and the disappearance time of mucopurulent stool in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). Conclusion Hedgehog Fungus Extract Granules combined with Mesalazine Enteric-Coated Tablets has clinical curative effect in treatment of ulcerative colitis, can improve the clinical symptoms of patients, and reduce the level of serum inflammatory factors, which has a certain clinical application value.