目的 研究红金消结胶囊联合注射用醋酸亮丙瑞林缓释微球治疗子宫内膜异位症的临床疗效。方法 选取2016年12月—2018年11月皖南医学院第二附属医院收治的86例子宫内膜异位症患者作为研究对象，每组各43例。对照组患者在月经周期第1天腹部皮下注射注射用醋酸亮丙瑞林缓释微球，3.75 mg/次。治疗组患者在对照组治疗的基础上口服红金消结胶囊，3粒/次，至经期停用。两组患者连续治疗3个月。观察两组的临床疗效，比较两组的血清指标、子宫内膜厚度、Kupperman评分。结果 治疗后，对照组和治疗组的总有效率分别为76.74%、93.02%，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清糖抗原125（CA125）、抗子宫内膜抗体（EMAb）、肝细胞生长因子（HGF）水平均显著降低，脂联素（APN）水平显著升高，与同组治疗前比较差异具有统计学意义（P<0.05）；且治疗组血清指标明显优于对照组，两组之间差异具有统计学意义（P<0.05）。治疗后，两组子宫内膜厚度明显缩小，Kupperman评分显著降低，与同组治疗前比较差异存在统计学意义（P<0.05）；且治疗组子宫内膜厚度、Kupperman评分明显低于对照组，两组之间差异具有统计学意义（P<0.05）。结论 红金消结胶囊联合注射用醋酸亮丙瑞林缓释微球治疗子宫内膜异位症具有较好的临床疗效，可改善患者的临床症状和体征，调节血清指标水平，具有一定的临床推广应用价值。

Objective To study the clinical effect of Hongjin Xiaojie Capsules combined with Leuprorelin Acetate Microspheres Sustained Release for injectio in treatment of endometriosis. Methods Patients (86 cases) with endometriosis in the Second Affiliated Hospital of Wannan Medical College from December 2016 to November 2018 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were abdominal subcutaneous injection administered with Leuprorelin Acetate Microspheres Sustained Release for injection on the first day of the menstrual cycle, 3.75 mg/time. Patients in the treatment group were po administered with Hongjin Xiaojie Capsules on the basis of the control group, 3 grains/time, and stopped in the menstruation period. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and serum indexes, endometrial thickness, and Kupperman scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.74% and 93.02%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of CA125, EMAb, and HGF in two groups were significantly decreased, but the levels of APN in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the serum indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, endometrial thickness and Kupperman scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Hongjin Xiaojie Capsules combined with Leuprorelin Acetate Microspheres Sustained Release for injection has clinical curative effect in treatment of endometriosis, can improve the clinical symptoms and signs of patients, regulate the level of serum indicators, which has a certain clinical application value.