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[摘要]
目的 研究石龙清血颗粒联合依达拉奉注射液治疗高血压脑出血的临床疗效。方法 选取2015年10月—2018年10月武警四川省总队医院收治的100例高血压脑出血患者研究对象,将所有患者随机分为对照组和治疗组,每组各50例。对照组患者静脉滴注依达拉奉注射液,30 mg/次,加入适量生理盐水中稀释后,30 min内滴完,2次/d;治疗组在对照组基础上口服石龙清血颗粒,1袋/次,3次/d。两组患者持续治疗4周。观察两组的临床疗效,比较两组的血肿周围水肿量、血肿量、格拉斯哥昏迷量表(GCS)评分以及超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平。结果 治疗后,对照组和治疗组的总有效率分别为82.00%、96.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血肿周围水肿量、血肿量显著降低,GCS评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血肿周围水肿量、血肿量和GCS评分明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者hs-CRP、TNF-α和IL-6水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组血清炎性因子水平显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论 石龙清血颗粒联合依达拉奉注射液治疗高血压脑出血具有较好的临床疗效,可减轻血肿周围水肿,减少颅内血肿,减轻脑损伤,改善患者神经功能,降低血清炎性因子水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To study the curative effect of Shilong Qingxue Granules combined with Edaravone Injection in treatment of hypertensive cerebral hemorrhage. Methods Patients (100 cases) with hypertensive cerebral hemorrhage in Sichuan Provincial Armed Police Headquarters Hospital from October 2015 to October 2018 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Edaravone Injection, 30 mg added into appropriate normal saline, and completed the drip in 30 min, twice daily. Patients in the treatment group were po administered with Shilong Qingxue Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and perihematoma edema, hematoma volume, and GCS scores, and the levels of hs-CRP, TNF-α and IL-6 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.00% and 96.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the perihematoma edema and the hematoma volume in two groups were significantly decreased, but the GCS scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of hs-CRP, TNF-α, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shilong Qingxue Granules combined with Edaravone Injection has a good clinical effect in the treatment of hypertensive intracerebral hemorrhage, which can reduce hematoma peripheral edema, reduce intracranial hematoma rapidly, reduce brain injury, and improve the neurological function of patients, which has a certain clinical application value.
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