目的 分析2016—2018年辽宁省肿瘤医院止吐药的使用情况，为临床合理使用止吐药提供参考。方法 对辽宁省肿瘤医院2016—2018年止吐药的使用金额、数量及其构成比、用药频度（DDDs）、日均费用（DDC）及药品排序比（B/A）进行统计分析。并比较不同剂型、不同作用分类、不同医保类别和各品种止吐药的使用情况。结果 止吐药的总使用金额和数量逐年增加，注射剂为主要给药形式。止吐药按作用机制分为3类，连续3年5-HT₃受体拮抗剂的使用金额和数量占99%以上。2016—2018年自费类止吐药的使用金额和数量构成比不断增长，2018年占80%以上。托烷司琼（5 mg）的DDDs值始终位于第1位。帕洛诺司琼（2 mg）在2016—2017年的DDC值最大，2018年阿瑞匹坦胶囊的DDC值最大。甲氧氯普胺的B/A值大于1，且一直位于首位。结论 辽宁省肿瘤医院止吐药的使用基本合理，具有药物的经济性和合理性。

Objective To analyze the usage of antiemetic drugs in Liaoning Cancer Hospital and Institute from 2016 to 2018, and to provide reference for the rational usage of antiemetic drugs in clinic. Methods Consumption sums, the quantities, the ratio, defined daily doses (DDDs), defined daily cost (DDC), and sorting ratio (B/A) of antiemetic drugs were statistically analyzed in Liaoning Cancer Hospital and Institute from 2016 to 2018. The usage of antiemetic drugs in different dosage forms, different effective classification, and different medical insurance categories were compared respectively, and each of antiemetic drugs was also analyzed comparatively. Results The total consumption sums and the quantities of antiemetic drugs increased year by year, and injections were the main dosage forms. Antiemetic drugs were divided into three categories according to the mechanism of action. Consumption sum and the quantity of 5-HT₃ receptor antagonists were more than 99% consecutively for three years. From 2016 to 2018, the ratio of consumption sum and the quantity for self-paid antiemetic drugs were ever-increasing, and were more than 80% in 2018. DDDs of tropisetron (5 mg) was always ranked the first. DDC of palonosetron (2 mg) was the highest in 2016 and 2017, and Aprepitant Capsules had the highest DDC value in 2018. The B/A value of metoclopramide was bigger than 1, and was always ranked the first. Conclusion The usage of antiemetic drugs in Liaoning Cancer Hospital and Institute is reasonable on the whole, which has the economy and rationality of drugs.