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[摘要]
目的 探讨达格列净片联合吡格列酮片治疗2型糖尿病的临床疗效。方法 选取2018年1月—2019年1月深圳市第二人民医院收治的86例2型糖尿病患者纳入本研究,根据用药方案之间的差异将患者分为对照组和治疗组,每组各43例。对照组于早饭前口服吡格列酮片,2片/次,1次/d。治疗组在对照组的基础上于早晨口服给予达格列净片,0.5片/次,1次/d。两组患者均治疗3个月。观察两组患者临床疗效,同时比较治疗前后两组患者血糖指标、氧化应激指标水平。结果 治疗后,对照组、治疗组总有效率分别为72.1%、90.7%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平均显著降低,胰高血糖素样肽1(GLP-1)水平显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组血糖指标均明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)、总抗氧化能力(T-Aoc)水平均显著升高,丙二醛(MDA)水平显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组氧化应激指标均明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 达格列净片联合吡格列酮片治疗2型糖尿病具有较好的临床疗效,可改善患者血糖水平,缓解氧化应激状态,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effects of Dapagliflozin Tablets combined with Pioglitazone Tablets in treatment of type 2 diabetes. Methods Patients (86 cases) with type 2 diabetes in Shenzhen No.2 People's Hospital from January 2018 to January 2019 were divided into control and treatment groups according to differences between regimens, and each group had 43 cases. Patients in the control group were po administered with Pioglitazone Tablets before breakfast, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Dapagliflozin Tablets at morning on the basis of the control group, 0.5 tablet/time, once daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and levels of blood glucose indexes and oxidative stress indicators before and after treatment in two groups were compared. Results After treatment, the clinical efficacy in the control group was 72.1%, which was significantly lower than 90.7% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the levels of FBG, 2 h PG, HbA1c, and FINS in two groups were significantly decreased, but GLP-1 levels were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the levels of blood glucose indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of GSH-PX, SOD, and T-Aoc in two groups were significantly increased, but MDA levels were significantly decreased (P<0.05). And the levels of oxidative stress indicators in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Dapagliflozin Tablets combined with Pioglitazone Tablets has a good effect in the treatment of type 2 diabetes, can improve blood sugar level and alleviate oxidative stress, which has a certain clinical application value.
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