目的 研究抗宫炎片联合重组人干扰素α2b凝胶治疗慢性宫颈炎的临床疗效。方法 选取2017年12月—2018年12月山东大学齐鲁医院（青岛）收治的100例慢性宫颈炎患者作为研究对象，将所患者随机分为对照组和治疗组，每组各50例。对照组患者晚睡前清洁外阴后在阴道深部放置重组人干扰素α2b凝胶，1 g/次，隔日一次；治疗组在对照组治疗的基础上口服抗宫炎片，6片/次，3次/d。两组患者持续治疗14 d。观察两组患者的临床疗效，比较两组治疗前后的临床症状缓解时间和血清炎性因子水平。结果 治疗后，对照组、治疗组总有效率分别为76.00%、94.00%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者阴道排液时间、宫颈修复时间显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血管内皮生长因子（VEGF）和自然杀伤T细胞（NKTs）水平均显著升高，白介素-2（IL-2）、白介素10（IL-10）和超敏C反应蛋白（hs-CRP）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组血清炎性因子水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 抗宫炎片联合重组人干扰素α2b凝胶治疗慢性宫颈炎具有较好的临床疗效，能够加速宫颈修复，降低血清炎性因子水平，值得在临床上推广应用。

Objective To study the efficacy of Kanggongyan Tablets combined with Recombinant Human Interferon α2b Gel in treatment of chronic cervicitis. Methods Women (100 cases) with chronic cervicitis in Qilu Hospital of Shandong University (Qingdao) from December 2017 to December 2018 were randomly divided into control and treatment groups, and each group had 50 cases. Women in the control group were given Recombinant Human Interferon α2b Gel after cleaning the vulva before going to bed at night and be placed deeply in the vagina, 1 g/time, every other day. Women in the treatment group were po administered with Kanggongyan Tablets on the basis of control group, 6 tablets/time, three times daily. Women in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and bleeding amount, hemostasis time, and clinical symptom relief times and serum inflammatory factor levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 76.00% and 94.00%, respectively, and there were differences between two groups (P<0.05). After treatment, cervical repair time and vaginal drainage time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of VEGF and NKTs in two groups were significantly increased, but the levels of IL-2, IL-10, and hs-CRP in two groups were significantly decreased (P<0.05). After treatment, the serum inflammatory factor levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Kanggongyan Tablets combined with Recombinant Human Interferon α2b Gel has a good clinical effect in the treatment of chronic cervicitis, can accelerate the cervical repair and reduce the levels of serum inflammatory factors, which has a certain clinical application value.