[关键词]
[摘要]
目的 探讨补肾固齿丸联合替硝唑口腔贴片治疗牙周炎的临床疗效。方法 选取2016年2月—2018年2月于重庆市垫江县人民医院治疗的96例(131颗患牙)牙周炎患者进行临床研究,将所有患者根据诊断顺序分为对照组(47例,65颗)和治疗组(49例,66颗)。对照组患者于患牙处贴替硝唑口腔贴片,1片/次,2次/d。治疗组在对照组基础上口服补肾固齿丸,4 g/次,2次/d。两组患者均连续3周。观察两组的临床疗效,比较两组的龈沟出血指数、牙龈指数、口腔健康相关生活质量(OHRQOL)评分、瘦素、细胞外弹性蛋白酶和白细胞介素6水平。结果 治疗后,对照组和治疗组的总有效率分别为83.08%、95.45%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者龈沟出血指数、牙龈指数均显著降低,OHRQOL评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患者龈沟出血指数、牙龈指数和OHRQOL评分显著优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者瘦素、细胞外弹性蛋白酶、白细胞介素6水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患者瘦素、细胞外弹性蛋白酶、白细胞介素6水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 补肾固齿丸联合替硝唑口腔贴片治疗牙周炎具有较好的临床疗效,能改善临床症状,安全性较好,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Bushen Guchi Pills combined with Tinidazole Oral Sticking Tablets in treatment of periodontitis. Methods Patients (96 cases; 131 teeth) with periodontitis in Dianjiang People's Hospital of Chongqing from February 2016 to February 2018 were randomly divided into the control group (47 cases; 65 teeth) and treatment group (49 cases; 66 teeth). Patients in the control group were given Tinidazole Oral Sticking Tablets to apply to affected teeth, 1 patch/time, twice daily. Patients in the treatment group were po administered with Bushen Guchi Pills on the basis of the control group, 4 g/time, twice daily. Patients in two groups were treated for 3 weeks. After treatment, the clinical efficacies were evaluated, and sulcus bleeding indexes, gingival indexes, OHRQOL scores, and the levels of leptin, extracellular elastase and IL-6 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.08% and 95.45%, respectively, and there was difference between two groups (P<0.05). After treatment, sulcus bleeding indexes and gingival indexes in two groups were significantly decreased, but OHRQOL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of leptin, extracellular elastase and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Bushen Guchi Pills combined with Tinidazole Oral Sticking Tablets has clinical curative effect in treatment of periodontitis, can improve clinical symptoms, with good safety, which has a certain clinical application value.
[中图分类号]
[基金项目]