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[摘要]
目的 探讨胃苏颗粒联合维酶素片治疗慢性萎缩性胃炎的临床疗效。方法 选取2016年8月—2018年8月于武汉市第五医院诊疗的慢性萎缩性胃炎患者142例为研究对象,随机分为对照组和治疗组,每组各71例。对照组患者口服维酶素片,4片/次,3次/d。治疗组在对照组治疗基础上口服胃苏颗粒,服用前用适量开水冲服,1袋/次,3次/d。两组患者均连续治疗30 d。观察两组的临床疗效,比较两组治疗前后胃黏膜组织病理评分、症状积分、生活质量评分及血清生化指标的变化情况。结果 治疗后,对照组和治疗组的总有效率分别是87.32%、97.18%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组胃黏膜组织病理评分、症状积分均较治疗前显著降低,而生活质量评分均较治疗前显著升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组胃黏膜组织病理评分、症状积分均显著低于对照组,而生活质量评分高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组胃泌素17(G-17)、胃蛋白酶原I(PG I)/胃蛋白酶原Ⅱ(PG Ⅱ)水平均较治疗前显著升高,而表皮生长因子(EGF)水平均较治疗前显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组G-17、PG I/PG Ⅱ水平高于对照组,而EGF水平低于对照组,两组比较差异有统计学意义(P<0.05)。结论 胃苏颗粒联合维酶素片治疗慢性萎缩性胃炎疗效显著,能够显著改善患者的临床症状和生活质量,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Weisu Granules combined with vitacoenzyme in treatment of chronic atrophic gastritis. Methods Patients (142 cases) with chronic atrophic gastritis in Wuhan Fifth Hospital from August 2016 to August 2018 were randomly divided into control (71 cases) and treatment (71 cases) groups. Patients in the control group were po administered with Vitacoenzyme Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Weisu Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacy was evaluated, and the changes of pathological score, symptom score, life quality score and serum biochemical indexes of gastric mucosa in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 87.32% and 97.18%, respectively, and there were differences between two groups (P<0.05). After treatment, pathological score and symptom score in two groups were significantly decreased, but life quality scores were significantly increased, and there were differences in the same group (P<0.05). After treatment, pathological score and symptom score in the control group were significantly lower than those in the control group, but life quality score was significantly higher than that in the control group, and there were differences between two groups (P<0.05). After treatment, G-17 and PG I/PG Ⅱ in two groups were significantly increased, but EGF was significantly decreased, and there were differences in the same group (P<0.05). After treatment, G-17 and PG I/PG Ⅱ in the control group were significantly higher than those in the control group, but EGF was significantly lower than that in the control group, and there were differences between two groups (P<0.05). Conclusion Weisu Granules combined with vitacoenzyme has significant effect in treatment of chronic atrophic gastritis, and can significantly improve clinical symptoms and life quality, which has a certain clinical application value.
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