洛沙坦是常用的血管紧张素Ⅱ受体拮抗剂，在治疗高血压等心血管疾病中具有重要作用，临床实践发现不同个体对洛沙坦的反应差异大，研究表明遗传因素是导致洛沙坦疗效产生个体差异的重要因素之一。主要对洛沙坦基因遗传多态性的研究进展进行综述。

Losartan is a common angiotensinⅡ receptor antagonist which plays an important role in antihypertension. However, it is found that different patients had different responses after taking losartan in clinical practice. Genetic factor may be one of explanation of this phenomenon. Now, research progress on genetic polymorphism of lasartan is reviewed in this paper.