目的 分析辽宁省肿瘤医院保肝药物的使用情况及用药趋势，为临床合理用药提供参考。方法 收集辽宁省肿瘤医院2015-2017年保肝药物的应用数据，对销售金额、用药频度（DDDs）、日均药费（DDC）及药品排序比（B/A）等进行统计和分析。结果 2015-2017年保肝药物的销售金额及DDDs呈逐年增长趋势，其中注射用复方二氯醋酸二异丙胺和脱氧核苷酸钠注射液连续3年居前2位。注射用复合辅酶、异甘草酸镁注射液和注射用门冬氨酸鸟氨酸的DDC居前3位。B/A接近于1的药品包括注射用复方二氯醋酸二异丙胺、脱氧核苷酸钠注射液、注射用硫普罗宁和丁二磺酸腺苷蛋氨酸片。结论 辽宁省肿瘤医院保肝药物的使用基本合理，但仍需加强监督管理，规范使用行为。

Objective To investigate the usage and variation tendency of hepatoprotective drugs in Liaoning Cancer Hospital and Institute, in order to provide reference for rational use of drugs in clinic. Methods The data of hepatoprotective drugs in Liaoning Cancer Hospital and Institute from 2015 to 2017 was collected, and consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were calculated and analyzed. Results From 2015to 2017, consumption sums and DDDs of hepatoprotective drugs increased year by year. Consumption sum and DDDs of Compound Diisopropylamine Dichloroacetate for injection and Sodium Deoxyribonucleotide Injection ranked the top two during three years. DDC of Coenzyme Complex for injection, Magnesium Isoglycyrrhizinate Injection, and L-ornithine L-aspartate for injection ranked the top three. B/A of Compound Diisopropylamine Dichloroacetate for injection, Sodium Deoxyribonucleotide Injection, Tiopronin for injection and Ademetionine 1, 4-Butanedisulfonate Tablets were close to 1. Conclusion The utilization of hepatoprotective drugs in Liaoning Cancer Hospital and Institute is basically reasonable, but the supervision and management still need to be strengthened to standardize usage behavior.