目的 评价和分析天津市津南区咸水沽医院2015-2017年抗菌药物的使用情况及变化趋势，为临床应用抗菌药物的合理性和科学性提供参考依据。方法 从天津市津南区咸水沽医院HIS系统中调取2015-2017年的抗菌药物数据进行回顾性分析，对不同剂型抗菌药物的销售金额、用药频度（DDDs）、日均费用（DDC））和排序比（B/A）等进行统计分析。结果 2015-2017年口服和注射剂型抗菌药物的销售金额均呈逐年上升趋势，2017年，氨基糖苷类的销售金额跃居第1位。头孢丙烯分散片于2016、2017年连续两年销售金额和DDDs排名居首位。口服抗菌药物的DDC值较低。大部分口服抗菌药物的B/A接近于1.00。盐酸莫西沙星注射液于2017年销售金额排名跃居首位，2016-2017年，注射用美罗培南的销售金额位居第2位。甲磺酸左氧氟沙星氯化钠注射液的DDDs排名位居前3位。注射剂型抗菌药物的DDC值一般较高。大部分注射剂型抗菌药物的B/A接近于1.00。结论 天津市津南区咸水沽医院2015-2017年抗菌药物临床应用总体上比较规范和合理，基本符合抗菌药物的用药规律。

Objective To evaluate and analyze the use and trends of antibiotics in Jinnan Xianshuigu Hospital of Tianjin City from 2015 to 2017, and provide reference for the rationality and scientificity of clinical application of antimicrobial agents. Methods The antibiotics data from 2015 to 2017 were retrieved from the HIS system of Jinnan Xianshuigu Hospital of Tianjin City for retrospective analysis. Consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) of antibacterial drugs in different forms were analyzed retrospectively. Results From 2015 to 2017, consumption sum of oral and injectable antibacterial drugs showed an increasing trend year by year. Consumption sum of aminoglycosides jumped to the first place in 2017. Consumption sum and DDDs of Cefprozil Dispersible Tablets ranked the first in 2016 and 2017. DDC of most oral antibacterial drugs were lower. And B/A of most oral antibacterial drugs were close to 1.00. Consumption sum of Moxifloxacin Hydrochloride Injection jumped to the first place in 2017. From 2016 to 2017, consumption sum of Meropenem for injection ranked the second. DDDs of Levofloxacin Mesylate Sodium Chloride Injection ranked the first three. DDC of most injectable antibacterial drugs were higher. And B/A of most oral antibacterial drugs were close to 1.00. Conclusion The clinical application of antibacterial drugs in Jinnan Xianshuigu Hospital of Tianjin City is generally standardized and reasonable from 2015 to 2017, which basically conforms to the law of drug use of antibacterial drugs.