目的 探讨糖维胶囊联合阿格列汀治疗2型糖尿病的临床疗效。方法 选取2015年6月-2018年6月在驻马店市中心医院治疗的2型糖尿病患者132例，根据住院号分为对照组（66例）和治疗组（66例）。对照组口服苯甲酸阿格列汀片，25 mg/次，1次/d；治疗组在对照组基础上口服糖维胶囊，2.5 g/次，3次/d。两组均连续治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者血糖相关指标、血糖波动情况和炎性指标。结果 治疗后，对照组临床有效率为81.82%，显著低于治疗组的96.97%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组空腹血糖（FBG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、胰岛素（FINS）、超敏C反应蛋白（hs-CRP）、血管细胞黏附分子-1（VCAM-1）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、富含半胱氨酸酸性分泌蛋白（SPARC）、血糖标准差（SDBG）、平均血糖波动幅度（MAGE）、24 h血糖波动次数（NGE）和24 h血糖平均绝对差（MODD）水平明显降低（P<0.05），同组比较差异具有统计学意义（P<0.05）；且治疗后治疗组患者上述指标水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 糖维胶囊联合苯甲酸阿格列汀片治疗2型糖尿病可有效降低机体血糖水平和炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Tangwei Capsules combined with alogliptin in treatment of type 2 diabetes. Methods Patients (132 cases) with type 2 diabetes in Zhumadian Central Hospital from June 2015 to June 2018 were divided into control (66 cases) and treatment (66 cases) groups based on admission number. Patients in the control group were po administered with Alogliptin Benzoate Tablets, 25 mg/time, once daily. Patients in the treatment group were po administered with Tangwei Capsules on the basis of the control group, 2.5 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the glucose related indicators, the blood glucose fluctuation and the inflammatory indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.82%, which was significantly lower than 96.97% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the FPG, 2 h PG, HbAlc, FINS, SDBG, MAGE, NGE, MODD, hs-CRP VCAM-1, SPARC, IL-6, and TNF-α levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05), and these indicators levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Tangwei Capsules combined with alogliptin in treatment of type 2 diabetes can effectively reduce the blood glucose level and inflammatory response, which has a certain clinical application value.