目的 探讨牙痛宁滴丸联合甲硝唑芬布芬胶囊治疗牙周炎的临床疗效。方法 选取2017年7月-2018年7月在石家庄市第三医院诊治的牙周炎患者124例作为研究对象，根据用药的不同将所有患者分为对照组（62例）和治疗组（62例）。对照组患者口服甲硝唑芬布芬胶囊，2粒/次，3次/d；治疗组在对照组基础上口服牙痛宁滴丸，10丸/次，3次/d。两组患者均连续治疗2周。观察两组患者的临床疗效，同时比较两组治疗前后的牙周指标、OHIP-14评分、VAS评分、炎症指标和唾液中氧化应激因子水平。结果 治疗后，对照组和治疗组总有效率分别为82.26%、96.77%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组临床探诊深度（PD）、龈沟出血指数（SBI）、菌斑指数（PLI）、临床附着水平（CAL）均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组各项牙周指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组OHIP-14评分、VAS评分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组OHIP-14评分、VAS评分显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、白细胞介素-17（IL-17）和基质金属蛋白酶-8（MMP-8）水平均显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组炎症因子水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组唾液中丙二醛（MDA）水平均显著降低，超氧化物歧化酶（SOD）水平明显增高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组氧化应激因子水平显著优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 牙痛宁滴丸联合甲硝唑芬布芬胶囊治疗牙周炎可有效改善口腔健康状况，促进牙周指标改善，降低血清炎症水平，改善机体氧化应激状态，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Yatongning Dropping Pills combined with Metronidazole and Fenbufen Capsules in the treatment of periodontitis. Methods Patients (124 cases) with periodontitis in Shijiazhuang the Third Hospital from July 2017 to July 2018 were divided into control (62 cases) and treatment (62 cases) groups according to the different medication. Patients in the control group were po administered with Metronidazole and Fenbufen Capsules, 2 grains/times, three times daily. Patients in the treatment group were po administered with Yatongning Dropping Pills on the basis of the control group, 10 pills/times, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the periodontal indexes, OHIP-14 scores, VAS scores, inflammatory markers, and oxidative stress factors in saliva in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.26% and 96.77%, respectively, and there was difference between two groups (P < 0.05). After treatment, PD, SBI, PLI, and CAL in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, OHIP-14 scores and VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, OHIP-14 scores and VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, IL-Iβ, TNF-α, IL-17, and MMP-8 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, inflammatory factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, MDA level was significantly decreased, but SOD level was significantly increased, and there were differences in the same group (P < 0.05). After treatment, oxidative stress factors levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yatongning Dropping Pills combined with Metronidazole and Fenbufen Capsules in the treatment of periodontitis can effectively improve the oral health, promote the improvement of periodontal indexes, reduce the levels of serum inflammation, and improve the oxidative stress state, which has a certain clinical application value.