目的 探讨口炎清颗粒联合甲硝唑片治疗慢性牙周炎的临床疗效。方法 选取2017年4月-2018年7月秦皇岛市第二医院收治的慢性牙周炎患者120例作为研究对象，按照随机数字表法分为对照组和治疗组，每组各有60例。对照组口服甲硝唑片，0.6 g/次，3次/d。治疗组在对照组治疗的基础上口服口炎清颗粒，10 g/次，2次/d。两组患者连续治疗4周。观察两组的临床疗效，比较两组的牙周指标和炎症因子。结果 治疗后，对照组、治疗组的总有效率分别为80.00%、91.67%，两组比较差异有统计学意义（P<0.05）。治疗后，两组的牙周袋深度（PD）、附着丧失水平（AL）、龈沟出血指数（SBI）、菌斑指数（PLI）均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组的PD、AL、SBI、PLI明显低于对照组，两组差异有统计学意义（P<0.05）。治疗后，两组的高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1 β（IL-1 β）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组的炎症因子水平均明显低于对照组，两组差异有统计学意义（P<0.05）。结论 口炎清颗粒联合甲硝唑片治疗慢性牙周炎具有较好的疗效，可改善牙周症状，降低炎症因子的水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Kouyanqing Granules combined with Metronidazole Tablets in treatment of chronic periodontitis. Methods Patients (120 cases) with chronic periodontitis in the Second Hospital of Qinhuangdao from April 2017 to July 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Metronidazole Tablets, 0.6 g/time, three times daily. Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes and inflammatory factors in two group were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 91.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, PD, AL, SBI, and PLI in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, TNF-α, IL-6, and IL-1β in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Kouyanqing Granules combined with Metronidazole Tablets has clinical curative effect in treatment of chronic periodontitis, can improve periodontal symptoms, and reduce the level of inflammatory factors, which has a certain clinical application value.