目的 研究甘草锌颗粒联合蒙脱石散治疗复发性口腔溃疡的临床疗效。方法 选取2015年8月-2017年8月天津市职业病防治院收治的120例复发性口腔溃疡患者为研究对象，将患者随机分为对照组和治疗组，每组各60例。对照组给予蒙脱石散，3 g/d，以温水调成乳状混合剂，饭后清水漱口，以无菌棉签蘸取混合剂涂擦在口腔溃疡处，涂抹后30 min内不进食水，每日涂抹3~4次。治疗组在对照组的基础上口服甘草锌颗粒，5 g/次，2次/d。两组患者均连续用药14 d。观察两组患者的临床疗效，同时比较两组患者的临床症状改善时间、血清炎症因子水平、VAS评分和溃疡复发情况。结果 治疗后，对照组和治疗组的总有效率分别为80.00%、96.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组的红肿消退时间、病痛消退时间和溃疡面愈合时间均明显短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的肿瘤坏死因子-α（TNF-α）、白细胞介素-4（IL-4）、白细胞介素-6（IL-6）水平和VAS评分显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血清炎症因子水平和VAS评分显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组复发率分别为51.67%、21.67%，两组比较差异具有统计学意义（P<0.05）。结论 甘草锌颗粒联合蒙脱石散治疗复发性口腔溃疡具有较好的临床疗效，能有效抑制炎性因子水平，减轻临床症状，降低复发风险，具有一定的临床推广应用价值。

Objective To study the clinical efficacy of Licorzine Granules combined with Montmorillonite Powder in treatment of recurrent oral ulcer. Methods Patients (120 cases) with recurrent oral ulcer in Tianjin Occupational Diseases Precaution and Therapeutic Hospital from August 2015 to August 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were given Montmorillonite Powder for 3 g daily, mixed with warm water into an emulsion mixture, rinsed with water after meals, dipped in a sterile cotton swab, and smeared with the mixture on the oral ulcer. No water was taken within 30 min after smearing, and smeared 3-4 times daily. Patients in the treatment group were po administered with Licorzine Granules on the basis of the control group, 5 g/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the clinical symptom improvement time, serum inflammatory factors levels, VAS scores, and the recurrence of ulcer in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.00% and 96.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, the swelling subsidence time, pain subsidence time, and ulcer healing time in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P < 0.05). After treatment, TNF-α, IL-4, and IL-6 levels, and VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the serum inflammatory factors levels and VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the recurrence rates in the control and treatment groups were 51.67% and 21.67%, respectively, and there were differences between two groups (P < 0.05). Conclusion Licorzine Granules combined with Montmorillonite Powder has good clinical efficacy in treatment of recurrent oral ulcer, can effectively inhibit the levels of inflammatory factors, reduce clinical symptoms, and decreased the risk of recurrence, which has a certain clinical application value.