目的 研究小儿豉翘清热颗粒联合热毒宁注射液治疗小儿疱疹性咽峡炎的临床疗效。方法 选取2017年1月-2018年6月泰州市人民医院收治的小儿疱疹性咽峡炎患者106例，随机分为对照组（54例）和治疗组（52例）。对照组患儿静脉滴注热毒宁注射液，0.6 mL/kg加入5%的葡萄糖注射液100 mL，最大剂量不超过10 mL，1次/d。治疗组在对照组基础上口服小儿豉翘清热颗粒，1~3岁2~3 g/次，4~6岁3~4 g/次，7~9岁4~5 g/次，3次/d。两组患者均连续治疗5~7 d。观察两组患者临床疗效，同时比较治疗前后两组患者炎症因子和免疫球蛋白水平及临床症状改善情况。结果 治疗后，对照组临床有效率为83.33%，显著低于治疗组的96.15%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者白介素-6（IL-6）、C-反应蛋白（CRP）、降钙素原（PCT）水平明显降低（P<0.05），且治疗组患者IL-6、CRP、PCT水平明显低于对照组（P<0.05）。治疗后，两组免疫球蛋白A（IgA）、IgG水平较治疗前明显升高（P<0.05），IgM水平明显降低（P<0.05），且治疗组患者IgA、IgG和IgM水平明显优于对照组（P<0.05）。治疗后，治疗组退热时间、疱疹消退时间和食欲恢复时间比对照组均明显缩短，两组比较差异具有统计学意义（P<0.05）。结论 小儿豉翘清热颗粒联合热毒宁注射液治疗小儿疱疹性咽峡炎临床效果确切，能明显改善症状，降低炎症水平，提高免疫功能。

Objective To study the clinical efficacy of Xiaoer Chiqiao Qingre Granules combined with Reduning Injection in treatment of herpangina in Children. Methods Children (106 cases) with herpangina in Jiangsu Taizhou People's Hospital from January 2017 to June 2018 were randomly divided into control (54 cases) and treatment (52 cases) groups. Children in the control group were iv administered with Reduning Injection, 0.6 mL/kg added into 5% glucose injection 100 mL, the maximum dose was less than 10 mL, once daily. Children in the treatment group were po administered with Xiaoer Chiqiao Qingre Granules on the basis of the control group, 2-3 g/time for 1-3 years children, 3-4 g/time for 4-6 years children, 4-5 g/time for 7-9 years children, once daily. Children in two groups were treated for 5-7 d. After treatment, the clinical efficacy was evaluated, and the inflammatory factors and immune protein levels, and the improvement of clinical symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 83.33%, which was significantly lower than 96.15% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the IL-6, CRP, and PCT levels in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the IgA and IgG levels in two groups were significantly increased (P < 0.05), but IgM levels were significantly decreased (P < 0.05), and these immune protein levels in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the antipyretic time, herpes subsidence time and appetite recovery time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). Conclusion The clinical efficacy of Xiaoer Chiqiao Qingre Granules combined with Reduning Injection in treatment of herpangina in children is positive, and the combined regimen can obviously improve the clinical symptom, reduce inflammation level and improve immune function.

泰州市科技社会发展项目（2013031）