目的 探讨抗感颗粒联合奥司他韦治疗小儿流行性感冒的临床效果。方法 选取2016年6月-2018年12月亳州市人民医院收治的62例流行性感冒患儿，按照随机数字表法随机分为对照组和治疗组，每组各31例。对照组口服磷酸奥司他韦颗粒，体质量 ≤ 15 kg者，30 mg/次，2次/d；>15~23 kg者，45 mg/次，2次/d；>23~40 kg者，60 mg/次，2次/d；>40 kg者，75 mg/次，2次/d。治疗组在对照组治疗基础上口服抗感颗粒，1~5岁者，0.5袋/次，3次/d；6~9岁者，1袋/次，3次/d；10~14岁者，1.5袋/次，3次/d；开水冲服。两组患儿均连续治疗5 d。观察两组的临床疗效，比较两组主要症状积分、症状改善时间、血象情况和C反应蛋白的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是80.65%、100.0%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组发热积分、咽黏膜充血积分、咳嗽积分、咳痰黄稠积分均较治疗前显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组这些症状积分显著低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，对照组和治疗组的即刻退热率分别是35.5%、61.3%，两组比较差异具有统计学意义（P<0.05）；治疗组起效时间和体温恢复正常时间均显著短于对照组，两组比较差异具统计学意义（P<0.05）。治疗后，两组白细胞总数（TWBC）、中性粒细胞比例（NETU%）异常例数和异常率均较治疗前显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组TWBC、NETU%异常例数和异常率显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组C反应蛋白（CRP）较治疗前显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组CRP水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 抗感颗粒联合奥司他韦治疗小儿流行性感冒具有较好的临床疗效，可明显减轻患儿风热犯表证的相关症状，退热效果显著，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Kanggan Granules combined with oseltamivir in treatment of infantile influenza. Methods Children (62 cases) with influenza in Bozhou People's Hospital from June 2016 to December 2018 were randomly divided into control (31 cases) and treatment (31 cases) groups according to the random number table method. Children in the control group were po administered with Oseltamivir Phosphate Granules, body mass ≤ 15 kg, 30 mg/time, twice daily; body mass > 15-23 kg, 45 mg/time, twice daily; body mass > 23-40 kg, 60 mg/time, twice daily; body mass > 40 kg, 75 mg/time, twice daily. Children in the treatment group were po administered with Kanggan Granules on the basis of the control group, for 1-5 years old, 0.5 bag/time, three times daily; 6-9 years old, 1 bag/time, three times daily; 10-14 years old, 1.5 bag/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the main symptom score, symptom improvement time, blood condition and CRP were compared between the two groups. Results After treatment, the clinical efficacy in the control and treatment groups were 80.65% and 100.00%, respectively, and there were differences between two groups (P < 0.05). After treatment, the fever score, pharyngeal mucosa hyperemia score, cough score and expectoration yellow thickening score in two groups were significantly lower, and there were differences in the same group (P < 0.05). After treatment, those scores in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the immediate antipyretic rates in the control and treatment groups were 80.65% and 100.00%, respectively, and there were differences between two groups (P < 0.05). The onset time and body temperature recovery time in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P < 0.05). The abnormal cases and abnormal rate of TWBC and NETU% in two groups were significantly lower than those before treatment, and there were differences in the same group (P < 0.05). After treatment, the indicators in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, CRP in two groups were significantly lower, and there were differences in the same group (P < 0.05). After treatment, CRP in the treatment group was lower than that in the control group, and there were differences between two groups (P < 0.05). Conclusion Kanggan Granules combined with oseltamivir has significant effect in treatment of infantile influenza, and can significantly reduce the symptoms of wind-heat syndrome in children, and has significant antipyretic effect, which has a certain clinical application value.