目的 探讨珍菊降压片联合坎地沙坦酯片治疗高血压的临床疗效。方法 选取2015年2月-2017年2月郑州大学第一附属医院治疗的280例高血压患者作为研究对象，根据住院号的奇偶数将患者分为对照组（140例）和治疗组（140例）。对照组口服坎地沙坦酯片，8 mg/次，根据血压调整剂量，但不可超过12 mg；治疗组在对照组治疗的基础上口服珍菊降压片，0.3 g/次，3次/d。两组患者均治疗4周。观察两组患者的临床疗效，比较两组治疗前后的血压、血管内皮功能和炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为80.71%、96.43%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组收缩压（SBP）、舒张压（DBP）均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血压显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组肱动脉内皮依赖性舒张功能（EDD）、非内皮依赖血管舒张功能（NMD）均明显升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血管内皮功能明显高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清C反应蛋白（CRP）、基质金属蛋白酶-9（MMP-9）、可溶性细胞间黏附分子1（sICAM-1）、单核细胞趋化蛋白1（MCP-1）和血管性血友病因子（vWF）水平均均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组炎性因子水平均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 珍菊降压片联合坎地沙坦酯片治疗高血压可有效降低患者血压，促进血管内皮功能改善，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Zhenju Jiangya Tablets combined with Candesartan Cilexetil Tablets in treatment of hypertension. Methods Patients (280 cases) with hypertension in The First Affiliated Hospital of Zhengzhou University from February 2015 to February 2017 were divided into the control group (140 cases) and treatment group (140 cases) according to the odd and even number of hospitalization numbers. Patients in the control group were po administered with Candesartan Cilexetil Tablets, 8 mg/time, and adjusted the dose according to the blood pressure, but not more than 12 mg. Patients in the treatment group were po administered with Zhenju Jiangya Tablets on the basis of the control group, 0.3 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the blood pressure, vascular endothelial function, and serum levels of inflammatory factors in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.71% and 96.43%, respectively, and there were differences between two groups (P < 0.05). After treatment, SBP and DBP in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, the blood pressures in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, EDD and NMD in two groups were significantly increased, and there were differences in the same group (P < 0.05). After treatment, the vascular endothelial functions in the treatment group were higher than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the levels of CRP, MMP-9, sICAM-1, MCP-1, and vWF in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, the serum levels of inflammatory factors in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Zhenju Jiangya Tablets combined with Candesartan Cilexetil Tablets in treatment of hypertension can effectively reduce blood pressure, promote the improvement of vascular endothelial function, and reduce the body's inflammatory response, which has a certain clinical application value.

国家自然科学基金青年科学基金资助项目（81600290）