目的 探讨灯盏花素注射液联合注射用阿替普酶治疗急性心肌梗死的临床疗效。方法 选取2017年3月-2018年6月天津市宁河区医院收治的急性心肌梗死患者92例为研究对象，按照随机数字表法分为对照组和治疗组，每组各46例。对照组静脉注射注射用阿替普酶100 mg，先注射20 mg，30 min后注射30 mg，60 min后注射30 mg，最后20 mg在90 min内静脉滴注完毕。治疗组在对照组治疗的基础上静脉滴注灯盏花素注射液，10 mg加入到10%葡萄糖溶液500 mL中，1次/d。两组患者均连续治疗14 d。观察两组的临床疗效，比较两组的白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、肌酸激酶同工酶（CK-MB）、肌钙蛋白T（cTnT）、左室射血分数（EF）、左室舒张功能比值（E/A）。结果 治疗后，对照组和治疗组的总有效率分别为76.09%、91.30%，两组比较差异有统计学意义（P<0.05）。治疗后，两组IL-6、IL-1β水平较治疗前明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组IL-6、IL-1β水平均明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组CK-MB、cTnT水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后治疗组的CK-MB、cTnT水平均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组EF、E/A值较治疗前升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后治疗组EF、E/A值均高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 灯盏花素注射液联合注射用阿替普酶治疗急性心肌梗死的疗效确切，能降低炎症反应，减轻心肌细胞损伤，改善心肌功能，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Breviscapine Injection combined with Alteplase for injection in treatment of acute myocardial infarction. Methods Patients (92 cases) with acute myocardial infarction in Tianjin Ninghe District Hospital from March 2017 to June 2018 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were iv administered with Alteplase for injection 100 mg, the first 20 mg, 30 mg after 30 min, and 30 mg after 60 min, the last 20 mg within 90 min. Patients in the treatment group were iv administered with Breviscapine Injection on the basis of the control group, 10 mg added into 10% glucose solution 500 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and IL-6, IL-1β, CK-MB, cTnT, EF, and E/A in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.09% and 91.30%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of IL-6 and IL-1β in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of CK-MB and cTnT in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, EF and E/A in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Breviscapine Injection combined with Alteplase for injection has clinical curative effect in treatment of acute myocardial infarction, can reduce inflammation and myocardial cell damage, and improve myocardial function, which has a certain clinical application value.