目的 探讨注射用鼠神经生长因子联合单唾液酸四己糖神经节苷脂钠注射液治疗新生儿脑损伤的临床疗效。方法 选取2017年1月-2018年3月郑州大学第三附属医院收治的脑损伤患儿178例为研究对象，根据治疗方案分为对照组（98例）和治疗组（80例）。对照组静脉输注单唾液酸四己糖神经节苷脂钠注射液，20 mg/次，1次/d。治疗组在对照组治疗的基础上肌内注射注射用鼠神经生长因子，18 μg加入到生理盐水2 mL中，1次/d。两组均治疗10 d后停用20 d，30 d为1个疗程，连续治疗3个疗程。观察两组的临床疗效，比较两组的神经损伤指标、脑干听觉诱发电位和智力情况。结果 治疗后，对照组和治疗组的总有效率分别为83.67%、93.75%，两组比较差异有统计学意义（P<0.05）。治疗后，两组神经元特异性烯醇化酶（NSE）、髓鞘碱性蛋白（MBP）、S100β蛋白水平均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组神经损伤指标明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组潜伏期（PL）、峰间期（IPL）各级均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组脑干听觉诱发电位指标明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗3月后，两组盖泽尔发育量表适应性发育商（DQ）评分均明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组DQ评分明显高于对照组，两组比较差异有统计学意义（P<0.05）。结论 注射用鼠神经生长因子联合单唾液酸四己糖神经节苷脂钠注射液治疗新生儿脑损伤具有较好的临床疗效，能改善其智力和神经损伤程度，并缩短患儿脑干听觉诱发电位时长，具有一定的临床推广应用价值。

Objective To explore the clinical effects of mouse nerve growth factor combined with ganglioside in treatment of neonatal brain injury.Methods Children (178 cases) with brain injury in the Third Affiliated Hospital of Zhengzhou University from January 2017 to March 2018 were randomly divided into the control group (98 cases) and the treatment group (80 cases). Children in the control group were iv administered with Monosialotetrahexosylganlioside Sodium Injection, 20 mg/time, once daily. Patients in the treatment group were intramuscular injection administered with Mouse Nerve Growth Factor for injection on the basis of the control group, 18 μg added into normal saline 2 mL, once daily. Patients in two groups were discontinued for 20 d after treatment for 10 d. A course of treatment had 30 d, and patients in two groups were treated for 3 courses. After treatment, the clinical efficacies were evaluated, and nerve injury indexes, brainstem auditory evoked potential, and intelligence condition in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 83.67% and 93.75%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of NSE, MBP, S100β in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the grades of PL and IPL in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the DQ scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the DQ scores in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05).Conclusion Mouse nerve growth factor combined with ganglioside has clinical curative effect in treatment of neonatal brain injury, can improve the intelligence and nerve injury, and shorten the duration of brainstem auditory evoked potentials in children, which has a certain clinical application value.