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[摘要]
目的 研究舒脑欣滴丸联合腺苷钴胺治疗三叉神经痛患者的临床疗效。方法 选取2016年6月-2017年12月陕西中医药大学第二附属医院收治的三叉神经痛患者110例,随机分为对照组和治疗组,每组组各55例。对照组患者肌肉注射注射用腺苷钴胺,1次/d,1 mg/次。治疗组在对照组的基础上口服舒脑欣滴丸,4颗/次,3次/d。两组患者均治疗28 d。观察两组患者临床疗效,同时比较治疗前后两组患者VAS疼痛评分和匹兹堡睡眠质量指数量表(PSQI)评分及血清炎症因子、P物质(SP)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)水平。结果 治疗后,对照组临床有效率为80.00%,显著低于治疗组的96.36%,两组比较差异具有统计学意义(P<0.05)。治疗1、2、4周后,两组患者VAS疼痛评分均显著降低(P<0.05),且治疗组患者VAS疼痛评分比同期对照组患者明显降低(P<0.05)。治疗后,两组患者PSQI各项评分均显著下降(P<0.05),且治疗组PSQI各项评分明显低于对照组(P<0.05)。治疗后,两组患者血清C反应蛋白(CRP)、白细胞介素-1β(IL-1β)、IL-6、肿瘤坏死因子-α(TNF-α)及SP水平均显著降低(P<0.05),且治疗组上述因子水平明显低于对照组(P<0.05)。治疗后,两组患者血清SOD和GSH-Px水平显著高于治疗前(P<0.05),且治疗组明显高于对照组(P<0.05)。结论 舒脑欣滴丸联合腺苷钴胺治疗三叉神经痛疗效确切,可调节炎症反应,减少氧化应激水平,缓解疼痛症状,具有一定的临床推广应用价值。
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[Abstract]
Objective To study the clinical efficacy of Shunaoxin Dropping Pills combined with cobamamide in treatment of trigeminal neuralgia.Methods Patients (110 cases) with trigeminal neuralgia in the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from June 2016 to December 2017 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were intramuscular injection administered with Cobamamide for injection, 1 mg/time, once daily. Patients in the treatment group were po administered with Shunaoxin Dropping Pills on the basis of the control group, 4 pills/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacy was evaluated, and the VAS, PSQI scores, serum inflammatory factors, SP, SOD and GSH-Px levels in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control group was 80.00%, which was significantly lower than 96.36% in the treatment group, and there were differences between two groups (P<0.05). After treatment for 1, 2, and 4 weeks, the VAS scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the PSQI scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the CRP, IL-1β, IL-6, TNF-α and SP levels in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the SOD and GSH-Px levels in two groups were significantly increased (P<0.05), and which in the treatment group were significantly higher than those in the control group (P<0.05).Conclusion Shunaoxin Dropping Pills combined with cobamamide has significant effect in treatment of trigeminal neuralgia, can regulate inflammation, reduce oxidative stress and relieve pain symptoms, which has a certain clinical application value.
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