目的 探讨镇脑宁联合阿魏酸钠治疗偏头痛的有效性与安全性。方法 选取郑州人民医院2016年4月—2017年4月收治的偏头痛患者114例，按照就诊顺序分成对照组和治疗组，每组各57例。对照组患者口服阿魏酸钠片，2片/次，3次/d；治疗组患者在对照组治疗基础上口服镇脑宁胶囊，4粒/次，3次/d。两组患者治疗6个月。观察两组患者临床疗效，同时比较治疗前后两组患者头痛发作次数、持续时间和VAS评分及血清超敏C反应蛋白（hs-CRP）、同型半胱氨酸（Hcy）和基质金属蛋白酶9（MMP-9）水平。结果 治疗后，对照组和治疗组临床有效率分别为84.21%和96.49%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的头痛发作次数、持续时间和头痛VAS评分较治疗前均显著降低（P<0.05），且治疗组患者头痛发作次数、持续时间和VAS评分明显低于对照组（P<0.05）。治疗后，两组患者血清hs-CRP、Hcy和MMP-9水平显著降低（P<0.05），且治疗组患者血清hs-CRP、Hcy和MMP-9水平明显低于对照组（P<0.05）。结论 镇脑宁联合阿魏酸钠治疗偏头痛临床效果显著、安全性好，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy and safety of Zhennaoning Capsules combined with sodium ferulate in treatment of migraine. Methods Patients (114 cases) with migraine in People's Hospital of Zhengzhou from April 2016 to April 2017 were divided into control and treatment groups according to the order of the treatment, and each had 57 cases. Patients in the control group were po administered with Sodium Ferulate Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Zhennaoning Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was evaluated, and the frequency and duration of headache, and VAS scores, the serum hs-CRP, Hcy and VEGF levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 84.21% and 96.49% respectively, and there were differences between two groups (P<0.05). After treatment, the frequency and duration of headache, and VAS scores in two groups were significantly decreased (P<0.05), which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the hs- CRP, Hcy and MMP-9 levels in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Zhennaoning Capsules combined with sodium ferulate in treatment of migraine has significant clinical effect and high safety, which has a certain clinical application value.