目的 探讨香菊胶囊联合桉柠蒎肠溶软胶囊治疗慢性鼻窦炎的临床效果。方法 选取2016年1月—2018年3月延安大学咸阳医院收治的慢性鼻窦炎患者134例，随机分成对照组（67例）和治疗组（67例）。对照组餐前30 min口服桉柠蒎肠溶软胶囊，1粒/次，2次/d。治疗组在对照组基础上口服香菊胶囊，3粒/次，3次/d。两组均连续治疗3个月。观察两组患者临床疗效，同时比较治疗前后两组患者视觉模拟评分法（VAS）、Lund-Kennedy和鼻腔鼻窦结局测试-20（SNOT-20）评分以及嗜酸性粒细胞比率（EOS%）、白介素-6（IL-6）、IL-17水平。结果 治疗后，对照组和治疗组临床有效率分别为80.6%和92.5%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组VAS和鼻内镜Lund-Kennedy评分显著降低（P<0.05），且治疗组上述评分明显低于对照组（P<0.05）。治疗后，两组患者SNOT-20各指标评分及总分均显著下降（P<0.05），且治疗组SNOT-20评分明显低于对照组（P<0.05）。治疗后，两组外周血EOS%值及血浆IL-6、IL-17浓度均显著下降（P<0.05），且治疗组比对照组降低更明显（P<0.05）。结论 香菊胶囊联合桉柠蒎肠溶软胶囊治疗慢性鼻窦炎，能明显控制患者病情，降低外周血EOS%，下调血浆中炎症介质，提高生存质量。

Objective To explore the clinical efficacy of Xiangju Capsules combined with Limonene and Pinene Enteric Soft Capsules in treatment of chronic sinusitis. Methods Patients (134 cases) with chronic sinusitis in Xianyang Hospital of Yan'an University from January 2016 to March 2018 were randomly divided into control (67 cases) and treatment (67 cases) groups. Patients in the control group were po administered with Limonene and Pinene Enteric Soft Capsules 30 min before meals, 1 grain/time, twice daily. Patients in the treatment group were po administered with Xiangju Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the VAS, Lund-Kennedy and SNOT-20 scores, EOS%, IL-6, and IL-17 levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.6% and 92.5% respectively, and there were differences between two groups (P<0.05). After treatment, the VAS and Lund-Kennedy of nasal endoscopy scores in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the scores of each index of SNOT-20 and total scores in two groups were significantly decreased (P<0.05), and SNOT-20 scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the EOS% of peripheral blood, IL-6 and IL-17 levels in plasma in two groups were significantly decreased (P<0.05), and those indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Xiangju Capsules combined with Limonene and Pinene Enteric Soft Capsules in treatment of chronic sinusitis can significantly control the patients' condition, reduce the EOS% of peripheral blood, reduce the inflammatory mediators in plasma and improve the quality of life.