目的 探讨荆花胃康胶丸联合枸橼酸铋钾治疗消化性溃疡的临床疗效。方法 选取航空总医院2017年2月—2018年3月收治的消化性溃疡患者96例，随机分成对照组和治疗组，每组各48例。对照组口服枸橼酸铋钾颗粒，2 g/次，2次/d。治疗组在对照组基础上饭前口服荆花胃康胶丸，2粒/次，3次/d。两组患者连续治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者幽门螺杆菌根除率、免疫球蛋白和炎性因子水平。结果 治疗后，对照组临床有效率为85.42%，显著低于治疗组的97.92%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组幽门螺杆菌根除率为83.33%，显著高于对照组的45.83%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者免疫球蛋白G（IgG）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）水平明显升高（P<0.05），且治疗组免疫球蛋白IgG、IgA、IgM水平明显高于对照组（P<0.05）。治疗后，两组患者血清血清中超敏C反应蛋白（hs-CRP）、白细胞介素6（IL-6）、转化生长因子-β1（TGF-β1）、转化生长因子-α（TGF-α）水平明显降低（P<0.05），且治疗组这些炎性因子水平明显低于对照组（P<0.05）。结论 荆花胃康胶丸联合枸橼酸铋钾治疗消化性溃疡患者疗效确切，可有效改善血清炎症因子水平，增强机体免疫力，具有一定的临床推广应用价值。

Objective To investigate the curative effect of Jinghua Weikang Soft Capsules combined with bismuth potassium citrate in treatment of peptic ulcer. Methods Patients (96 cases) with peptic ulcer in Aviation Hospital from February 2017 to March 2018 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Bismuth Potassium Citrate Granules, 2 g/time, twice. Patients in the treatment group were po administered with Jinghua Weikang Soft Capsules before meals on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the eradication rate of Helicobacter pylori, the levels of immunoglobulin and inflammatory factors in two groups before and after treatment were compared. Results After treatment, the objective reaction rate in the control group was 85.42%, which was significantly lower than 97.92% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the eradication rate of H. pylori in the treatment group was 83.33%, which was significantly higher than 45.83% in the control group, and there were differences between two groups (P<0.05). After treatment, the IgG, IgA, and IgM levels in two groups were significantly increased (P<0.05), and the IgG, IgA, and IgM levels in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, the serum hs-CRP, IL-6, TGF-β1, and TGF-α levels in two groups were significantly decreased (P<0.05), and these inflammatory factors levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Jinghua Weikang Soft Capsules combined with bismuth potassium citrate has definite curative effect in treatment of peptic ulcer, which can effectively improve the level of serum inflammatory factors, enhance the immunity, which has a certain clinical application value.